全部文献期刊会议图书|学者科研项目
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作者:... Esmaeil Ebrahimie , Theresa E. Hickey , Wayne D. Tilley
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2020, Vol.199
摘要:Abstract(#br)Medroxyprogesterone acetate (MPA) is a first generation progestin that has been in clinical use for various hormonal conditions in women since the 1960s. Although developed as a progesterone receptor (PR) agonist, MPA also has strong binding affinity for other s...
作者:... Wayne D. Tilley , Rebecca L. Robker , Theresa E. Hickey
来源:[J].Endocrine(IF 2.25), 2015, Vol.48 (2), pp.686-695
摘要:Abstract(#br)Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothesised that KI...
作者:Theresa E. Hickey , Howard I. Scher ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.343-357
摘要:Abstract(#br)Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablat...
作者:Theresa E. Hickey , Lisa M. Butler
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.60-70
摘要:Abstract(#br)Synthetic progestins are used clinically to treat a variety of women’s health issues. Although progestins are designed to signal through the progesterone receptor (PR) to elicit specific pharmacological effects, they can also variably bind to and influence the a...
作者:Theresa E. Hickey , Lisa M. Butler ...
来源:[J].Cell Cycle(IF 5.243), 2012, Vol.11 (14), pp.2756-2761
摘要:To model the heterogeneity of breast cancer as observed in the clinic, we employed an ex vivo model of breast tumor tissue. This methodology maintained the histological integrity of the tumor tissue in unselected breast cancers, and importantly, the explants retained key molecula...
作者:... Nicola R. Dean , Wayne D. Tilley , Theresa E. Hickey
来源:[J].Journal of Mammary Gland Biology and Neoplasia(IF 7.524), 2019, Vol.24 (1), pp.99-108
摘要:Abstract(#br)Androgens influence mammary gland development but the specific role of the androgen receptor (AR) in mammary function is largely unknown. We identified cell subsets that express AR in vivo and determined the effect of AR activation and transgenic AR inhibition on sub...
作者:Theresa E. Hickey , Jane E. Armes
来源:[J].British Journal of Cancer(IF 5.082), 2018, Vol.119 (1Suppl 1), pp.1316-1325
摘要:Abstract(#br)Background(#br)Recent pre-clinical studies indicate that activated progesterone receptor (PR) (particularly the PR-B isoform) binds to oestrogen receptor-α (ER) and reprogrammes transcription toward better breast cancer outcomes. We investigated whether ER and ...
作者:Theresa E. Hickey , Gerard A. Tarulli ...
来源:[J].Nature Reviews Cancer(IF 35), 2017, Vol.17 (Suppl. 12B), pp.54-64
摘要:This Opinion article discusses many controversial issues surrounding the connections of progestogens, which stimulate the progesterone receptor, to breast cancer risk and their possible therapeutic use in breast cancer.(#br)Abstract(#br)Most breast cancers are driven by oest...
作者:... Reshma Shakya , Wayne D. Tilley , Theresa E. Hickey
来源:[J].Journal of Mammary Gland Biology and Neoplasia(IF 7.524), 2015, Vol.20 (1-2), pp.75-91
摘要:Abstract(#br)The hormone-sensing mammary epithelial cell (HS-MEC—expressing oestrogen receptor-alpha (ERα) and progesterone receptor (PGR)) is often represented as being terminally differentiated and lacking significant progenitor activity after puberty. Therefore while able...
作者:... Robert J. Norman , Wayne D. Tilley , Theresa E. Hickey
来源:[J].Fertility and Sterility(IF 4.174), 2013, Vol.99 (7), pp.2076-2083.e1
摘要:Objective(#br)To evaluate the expression and function of small glutamine-rich tetratricopeptide repeat–containing protein alpha (SGTA), an androgen receptor (AR) molecular chaperone, in human ovarian tissues.(#br)Design(#br)Examine the effect of SGTA on AR subcellular locali...

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