全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:François Noël , Thais E.T. Pompeu , Bruna C. Moura
来源:[J].Journal of Pharmacological and Toxicological Methods(IF 2.15), 2014, Vol.70 (1), pp.12-18Elsevier
摘要:Abstract(#br)Introduction(#br)Determination of the intrinsic efficacy of ligands at the 5-HT 1A receptor is important for selecting drug candidates, e.g. in the case of schizophrenia where partial agonism is a favorable property shared by different atypical antipsychotics.(#...
作者:Thais E.T. Pompeu , Fernando R.S. Alves ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2013, Vol.66, pp.122-134Elsevier
摘要:Abstract(#br)In an attempt to increase the affinity of our antipsychotic lead compound LASSBio-579 (1-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine; ( 2 )) for the 5-HT 2A receptor, we synthesized five new N -phenylpiperazine derivatives using a linear synt...
作者:Thais E.T. Pompeu , Daniel A. Rodrigues ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2013, Vol.62, pp.214-221Elsevier
摘要:Abstract(#br)Using a combination of docking and molecular dynamics simulations, we predicted that p -hydroxylation by CYP1A2 would be the main metabolic pathway for the 1-[1-(4-chlorophenyl)-1 H -4pyrazolylmethyl] phenylhexahydropiperazine, LASSBio-579 ( 3 ). As the result of a s...
作者:Thais E.T. Pompeu , Daniel A. Rodrigues ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2013, Vol.62, pp.214-221Elsevier
摘要:Abstract(#br)Using a combination of docking and molecular dynamics simulations, we predicted that p -hydroxylation by CYP1A2 would be the main metabolic pathway for the 1-[1-(4-chlorophenyl)-1 H -4pyrazolylmethyl] phenylhexahydropiperazine, LASSBio-579 ( 3 ). As the result of a s...
作者:Thais E.T. Pompeu , Diego A. Duarte ...
来源:[J].Frontiers in Pharmacology, 2019, Vol.10DOAJ
摘要:LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D2 receptor (D2R) ligand with antipsychotic-like activities in rodent models of schizophrenia. In order to better understand the molecular mechanism of action of LASSBio-579 and...
作者:Thais E.T. Pompeu , Thaise S. Martins ...
来源:[J].Behavioural Pharmacology(IF 2.301), 2016Wolters Kluwer
摘要:Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male Wistar rats and CF1 mice ...

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