全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Steffen Ormanns , Michael Haas ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors. Among the genetic alterations frequently found in PDAC, mutations in t...
作者:Steffen Ormanns , Gesa Schuebbe ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2019, Vol.38 (1), pp.1-11DOAJ
摘要:Abstract Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen recept...
作者:Steffen Ormanns , Michael Haas ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2017, Vol.18 (5)DOAJ
摘要:The role of the tumor suppressor mothers against decapentaplegic homolog 4 (SMAD4) has not yet been defined in patients (pts) with advanced pancreatic cancer (aPC). This translational research study was designed to evaluate the impact of tumoral SMAD4 loss on clinicopathological ...
作者:Steffen Ormanns , Silvio K Scheel ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition. Additionally, cellular stress is accompanied by endoplasmic reticulum-stress which induces a...
作者:Steffen Ormanns , Volker Heinemann ...
来源:[J].European Journal of Cancer(IF 5.061), 2014, Vol.50 (11), pp.1891-1899Elsevier
摘要:Abstract(#br)Background(#br)The role of human equilibrative nucleoside transporter 1 (hENT1) as a predictive biomarker for gemcitabine efficacy in advanced pancreatic cancer remains unclear to date.(#br)Patients and methods(#br)AIO-PK0104 was a German multicenter phase III t...
作者:Steffen Ormanns , Dominik Paul Modest ...
来源:[J].Pancreatology(IF 2.043), 2016, Vol.16 (4), pp.593-598Elsevier
摘要:Abstract(#br)Purpose(#br)Liver metastasis represents the first site of dissemination in >80% of metastatic pancreatic cancer (PC) patients. Pulmonary metastasis as first site of dissemination in PC is a rare event and might define a biologically distinct subgroup in metastat...
作者:Steffen Ormanns , Karan Nagar ...
来源:[J].Cell Stem Cell(IF 25.315), 2016, Vol.18 (4), pp.441-455Elsevier
摘要:Summary(#br)The existence of adult pancreatic progenitor cells has been debated. While some favor the concept of facultative progenitors involved in homeostasis and repair, neither a location nor markers for such cells have been defined. Using genetic lineage tracing, we show tha...
作者:Steffen Ormanns , Thomas Gress
来源:[J].Cancer Letters(IF 4.258), 2016, Vol.381 (1), pp.259-268Elsevier
摘要:Abstract(#br)Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this...
作者:Steffen Ormanns , Gerald Assmann ...
来源:[J].Journal of Cancer Research and Clinical Oncology(IF 2.914), 2014, Vol.140 (9), pp.1625-1628Springer
摘要:Abstract(#br) Purpose(#br)It has not yet been clearly defined whether anaplastic lymphoma kinase (ALK) expression can be detected in pancreatic ductal adenocarcinoma (PDAC).(#br) Methods(#br)Within a retrospective study, archival PDAC surgical specimens were screened for ALK expr...
作者:Steffen Ormanns , Rüdiger P. Laubender ...
来源:[J].Tumor Biology(IF 2.518), 2015, Vol.36 (4), pp.2631-2640Springer
摘要:Abstract(#br)The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced pancreatic cancer (PC). Patients (pts) with locally advanced or metastatic PC treated with first-line palliative chemotherapy were included. Among ...

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