全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Olena Skarlat , Ronny Hans , Stefan Schulte
来源:[J].Service Oriented Computing and Applications, 2017, Vol.11 (4), pp.411-426Springer
摘要:The use of cloud-based storage systems for storing data is a popular alternative to local storage systems. Beside several benefits of cloud-based storages, there are also downsides like vendor lock-in or unavailability. Moreover, the selection of the best fitting storage solution...
作者:Stefan Schulte , Michael Borkowski
来源:[J].Service Oriented Computing and Applications, 2017, Vol.11 (4), pp.427-443Springer
摘要:The Internet of Things (IoT) leads to an ever-growing presence of ubiquitous networked computing devices in public, business, and private spaces. These devices do not simply act as sensors, but feature computational, storage, and networking resources. Being located at the edge of...
作者:Stefan Schulte
来源:[J].Thrombosis Research(IF 3.133), 2014, Vol.134, pp.S72-S76Elsevier
摘要:Abstract(#br)The development of new and improved therapeutic options for the management of haemophilia is a great challenge for both physicians and manufacturers. After factor VIII concentrates became widely available, progress in medicine and advances in biotechnology led t...
作者:... Gerhard Dickneite , Stefan Schulte , Sabine Zollner
来源:[J].Thrombosis Research(IF 3.133), 2014, Vol.134 (2), pp.495-502Elsevier
摘要:Abstract(#br)Introduction(#br)A novel fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP) is currently undergoing clinical investigations.(#br)Objective(#br)This study was conducted to examine the biodistribution of rVIIa-FP in comparison to recombinant fa...
作者:... Nicolas Grammel , Hubert J. Metzner , Stefan Schulte
来源:[J].Thrombosis Research(IF 3.133), 2015, Vol.136 (2), pp.388-395Elsevier
摘要:Abstract(#br)rVIII-SingleChain is a novel recombinant single-chain factor VIII (FVIII) construct, comprising covalently bonded heavy and light chains. Post-translational modifications of FVIII affect physicochemical parameters, including hydrophobicity and charge. The most r...
作者:... Ingo Pragst , Gerhard Dickneite , Stefan Schulte
来源:[J].Thrombosis Research(IF 3.133), 2014, Vol.134 (1), pp.125-131Elsevier
摘要:Abstract(#br)Introduction(#br)rVIII-SingleChain (CSL627), a novel recombinant coagulation factor VIII (FVIII), is under investigation in a phase I/III clinical programme (AFFINITY) for the treatment of haemophilia A. Non-clinical studies were conducted to investigate the pha...
作者:... Gerhard Dickneite , Stefan Schulte , Sabine Zollner
来源:[J].Thrombosis Research(IF 3.133), 2014, Vol.133 (5), pp.900-907Elsevier
摘要:Abstract(#br)Introduction(#br)The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-b...
作者:Stefan Schulte
来源:[J].Thrombosis Research(IF 3.133), 2013, Vol.131, pp.S2-S6Elsevier
摘要:Abstract(#br)Albumin fusion technology has been used to enhance the pharmacokinetic properties of recombinant coagulation factors. The goal of linking albumin to coagulation factors is to extend the half-life of the coagulation factor, thereby allowing for less frequent dosing fo...
作者:... Ingo Pragst , Gerhard Dickneite , Stefan Schulte
来源:[J].Thrombosis Research(IF 3.133), 2013, Vol.132 (2), pp.280-287Elsevier
摘要:Abstract(#br)Introduction(#br)The preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII, was assessed in a series of animal studies.(#br)Materials and Methods(#br)In the tail-clip bleeding model, hemophilia A mice were in...

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