全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Xiaolong Wang , Xiaoming Fan , Stavros J. Hamodrakas
来源:[J].Computational and Mathematical Methods in Medicine(IF 0.791), 2015, Vol.2015Hindawi
摘要:Drug name recognition (DNR) is a critical step for drug information extraction. Machine learning-based methods have been widely used for DNR with various types of features such as part-of-speech, word shape, and dictionary feature. Features used in current machine learning-based ...
作者:... Vassilis Gionis , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2017, Vol.199 (2), pp.140-152Elsevier
摘要:Abstract(#br)Human islet amyloid polypeptide (hIAPP) is the major protein component of extracellular amyloid deposits, located in the islets of Langerhans, a hallmark of type II diabetes. The underlying mechanisms of IAPP aggregation have not yet been clearly defined, althou...
作者:... Vassiliki Magafa , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2018, Vol.203 (1), pp.27-36Elsevier
摘要:Abstract(#br)The Calcitonin-gene related peptide (CGRP) family is a group of peptide hormones, which consists of IAPP, calcitonin, adrenomedullin, intermedin, αCGRP and βCGRP. IAPP and calcitonin have been extensively associated with the formation of amyloid fibrils, causing...
作者:Kostas A. Triantaphyllopoulos , Fotis A. Baltoumas , Stavros J. Hamodrakas
来源:[J].Journal of Computer-Aided Molecular Design(IF 3.172), 2019, Vol.33 (2), pp.265-285Springer
摘要:Abstract(#br)Natural Resistance-Associated Macrophage Proteins are a family of transmembrane divalent metal ion transporters, with important implications in life of both bacteria and mammals. Among them, the Solute Carrier family 11 member A1 (SLC11A1) has been implicated wi...
作者:... Geoffrey J. Howlett , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2015, Vol.79, pp.711-718Elsevier
摘要:Abstract(#br)Apolipoprotein A-I (apoA-I) is the major component of high density lipoproteins and plays a vital role in reverse cholesterol transport. Lipid-free apoA-I is the main constituent of amyloid deposits found in atherosclerotic plaques, an acquired type of amyloidos...
作者:Georgios N. Tsaousis , Pantelis G. Bagos , Stavros J. Hamodrakas
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2014, Vol.1844 (2), pp.316-322Elsevier
摘要:Abstract(#br)During the last two decades a large number of computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the distribution of positively charged residues in ext...
作者:... Paraskevi L. Tsiolaki , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2016, Vol.195 (2), pp.179-189Elsevier
摘要:Abstract(#br)Several organisms exploit the extraordinary physical properties of amyloid fibrils forming natural protective amyloids, in an effort to support complex biological functions. Curli amyloid fibers are a major component of mature biofilms, which are produced by man...
作者:Vasiliki D. Kostiou , Margarita C. Theodoropoulou , Stavros J. Hamodrakas
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2016, Vol.1864 (5), pp.435-440Elsevier
摘要:Abstract(#br)Heterotrimeric G-proteins form a major protein family, which participates in signal transduction. They are composed of three subunits, Gα, Gβ and Gγ. The Gα subunit is further divided in four distinct families G s , G i/o , G q/11 and G 12/13 . The goal of this ...
作者:... Nikolaos N. Louros , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2015, Vol.191 (3), pp.272-280Elsevier
摘要:Abstract(#br)Amyloidogenic proteins like human Cystatin C (hCC) have been shown to form dimers and oligomers by exchange of subdomains of the monomeric proteins. Normally, the hCC monomer, a low molecular type 2 Cystatin, consists of 120 amino acid residues and functions as ...
作者:Paraskevi L. Tsiolaki , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].FEBS Letters(IF 3.582), 2015, Vol.589 (1), pp.159-164Elsevier
摘要:Abstract(#br)Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults....

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