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作者:... Vassilis Gionis , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2017, Vol.199 (2), pp.140-152
摘要:Abstract(#br)Human islet amyloid polypeptide (hIAPP) is the major protein component of extracellular amyloid deposits, located in the islets of Langerhans, a hallmark of type II diabetes. The underlying mechanisms of IAPP aggregation have not yet been clearly defined, althou...
作者:... Vassiliki Magafa , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2018, Vol.203 (1), pp.27-36
摘要:Abstract(#br)The Calcitonin-gene related peptide (CGRP) family is a group of peptide hormones, which consists of IAPP, calcitonin, adrenomedullin, intermedin, αCGRP and βCGRP. IAPP and calcitonin have been extensively associated with the formation of amyloid fibrils, causing...
作者:... Paraskevi L. Tsiolaki , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2016, Vol.195 (2), pp.179-189
摘要:Abstract(#br)Several organisms exploit the extraordinary physical properties of amyloid fibrils forming natural protective amyloids, in an effort to support complex biological functions. Curli amyloid fibers are a major component of mature biofilms, which are produced by man...
作者:Paraskevi L. Tsiolaki , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].FEBS Letters(IF 3.582), 2015, Vol.589 (1), pp.159-164
摘要:Abstract(#br)Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults....
作者:... Geoffrey J. Howlett , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2015, Vol.79, pp.711-718
摘要:Abstract(#br)Apolipoprotein A-I (apoA-I) is the major component of high density lipoproteins and plays a vital role in reverse cholesterol transport. Lipid-free apoA-I is the main constituent of amyloid deposits found in atherosclerotic plaques, an acquired type of amyloidos...
作者:... Nikolaos N. Louros , Stavros J. Hamodrakas , Vassiliki A. Iconomidou
来源:[J].Journal of Structural Biology(IF 3.361), 2015, Vol.191 (3), pp.272-280
摘要:Abstract(#br)Amyloidogenic proteins like human Cystatin C (hCC) have been shown to form dimers and oligomers by exchange of subdomains of the monomeric proteins. Normally, the hCC monomer, a low molecular type 2 Cystatin, consists of 120 amino acid residues and functions as ...
作者:Stavros J. Hamodrakas , Judith H. Willis , Vassiliki A. Iconomidou
来源:[J].Insect Biochemistry and Molecular Biology(IF 3.234), 2002, Vol.32 (11), pp.1577-1583
摘要:Abstract(#br)The nature of the interaction of insect cuticular proteins and chitin is unknown even though about half of the cuticular proteins sequenced thus far share a consensus region that has been predicted to be the site of chitin binding. We previously predicted the pr...
作者:Stavros J. Hamodrakas
来源:[J].Journal of Structural Biology(IF 3.361), 1997, Vol.118 (1), pp.23-30
摘要:Abstract(#br)Concanavalin A (Con A) is the best known plant lectin, with important biological properties arising from its specific saccharide-binding ability. Its exact biological role still remains unknown. The complex of Con A with 4′-methylumbelliferyl-α- d -glucopyranosi...
作者:Stavros J. Hamodrakas , Christina Liappa , Vassiliki A. Iconomidou
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2007, Vol.41 (3), pp.295-300
摘要:Abstract(#br)We combine the results of three prediction algorithms on a test set of 21 amyloidogenic proteins to predict amyloidogenic determinants. Two prediction algorithms are recently developed prediction algorithms of amyloidogenic stretches in protein sequences, wherea...
作者:Fotis A. Baltoumas , Margarita C. Theodoropoulou , Stavros J. Hamodrakas
来源:[J].Journal of Structural Biology(IF 3.361), 2013, Vol.182 (3), pp.209-218
摘要:Abstract(#br)G-protein coupled receptors (GPCRs) are one of the largest families of membrane receptors in eukaryotes. Heterotrimeric G-proteins, composed of α, β and γ subunits, are important molecular switches in the mediation of GPCR signaling. Receptor stimulation after t...

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