全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Stéphane Demphel , Christine Rasetti ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 1999, Vol.26 (1), pp.105-109
摘要:Abstract(#br)ABSTRACT. (±)-3-[ 11 C]Methyl-2-[4-[3-( tert -butylamino)-2-hydroxypropoxy]phenyl]-6-methoxy-4( 3H )-quinazolinone ([±]-[ 11 C]HX-CH 44) was labeled with carbon-11 using [ 11 C]iodomethane with the corresponding N -demethylated precursor. Then, 30–90 mCi (1...
作者:Stéphane Demphel , Heric Valette ...
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2005, Vol.64 (3), pp.348-354
摘要:Abstract(#br)Recently, a novel series of amidines has been described, exhibiting high NR2B-subtype selective N -methyl- D -aspartate (NMDA) antagonist activity with nanomolar or subnanomolar affinity. Within the styrylamidine subclass, ( E )- N -(2-methoxybenzyl)-3-phenyl-ac...
作者:Stéphane Demphel , JaganMohan Gopisetti ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2003, Vol.11 (24), pp.5333-5343
摘要:Abstract(#br)In recent years, there has been considerable effort to design and synthesize radiotracers suitable for use in Positron Emission Tomography (PET) imaging of the α4β2 neuronal nicotinic acetylcholine receptor (nAChR) subtype. A new fluoropyridinyl derivative of (−...
作者:Stéphane Demphel , Christine Coulon ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2006, Vol.33 (6), pp.785-795
摘要:Abstract(#br)FAUC346 ( N -[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzo[ b ]thiophene-2-carboxamide), an in vitro D 3 -selective ligand, and its normethyl derivative have been synthesized from commercially available 1-(2-substituted-phenyl)piperazines. FAUC346 has been l...
作者:Stéphane Demphel , Stéphane Le Helleix ...
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2011, Vol.70 (3), pp.489-497
摘要:Abstract(#br)Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amount...
作者:Stéphane Demphel , Françoise Hinnen ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2005, Vol.14 (4), pp.1115-1125
摘要:Abstract(#br)LBT-999 (8-(( E )-4-fluoro-but-2-enyl)-3β- p -tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester), a cocaine derivative belonging to a new generation of highly selective dopamine transporter (DAT) ligands, and its corresponding carboxylic acid deri...
作者:Stéphane Demphel , Françoise Hinnen ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2008, Vol.97 (7), pp.2811-2819
摘要:Abstract(#br)In vivo pharmacokinetic and brain binding characteristics of (+)-[ 11 C]A-69024, a high-affinity-D1-selective dopamine receptor antagonist, were assessed with micro-PET and β-microprobes in the rat and PET in the baboon. The biodistribution of (+)-[ 11 C]A-69024...
作者:Stéphane Demphel , Françoise Hinnen ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2008, Vol.97 (7), pp.2811-2819
摘要:Abstract(#br)In vivo pharmacokinetic and brain binding characteristics of (+)‐[11C]A‐69024, a high‐affinity‐D1‐selective dopamine receptor antagonist, were assessed with micro‐PET and β‐microprobes in the rat and PET in the baboon. The biodistributi...
作者:Stéphane Demphel , Françoise Hinnen ...
来源:[J].Journal of Labelled Compounds and Radiopharmaceuticals(IF 1.24), 1998, Vol.41 (2), pp.105-114
摘要:Abstract(#br)This paper describes a short and simple synthesis of a new fully protected stannylated precursor, namely N ‐( tert ‐butoxycarbonyl)‐3,4‐di( tert ‐butoxycarbonyloxy)‐6‐trimethylstannyl‐ L ‐phenylalanine ethyl ester, for the preparation of 6‐[<...
作者:Stéphane Demphel , Christian Crouzel
来源:[J].Journal of Labelled Compounds and Radiopharmaceuticals(IF 1.24), 2000, Vol.43 (4), pp.331-338
摘要:Abstract(#br)[11C]FLB 457 is a high affinity dopamine D2 receptor radioligand that is used for visualisation and quantitation of extrastriatal dopamine D2 receptors with positron emission tomography (PET). In this study, we report a compariso...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×