全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Singh Kh Dhanachandra , Muthusamy Karthikeyan
来源:[J].Indian journal of microbiology(IF 0.457), 2009, Vol.49 (4), pp.358-64PubMed
摘要:The H1N1 2009 virus is pandemic in many countries. The genome of this virus contains eight segments. Among the eight segments maximum numbers of mutation occur at the segment 1 and segment 4 which codes for PB2 subunit and hemagglutinin (HA) and less number of mutations occu...
作者:Singh Kh Dhanachandra , Nagamani Selvaraman ...
来源:[J].Bioinformation, 2011, Vol.6 (3), pp.100-6PubMed
摘要:Glioblastoma multiforme (GBM) is considered to be the most common and often deadly disorder which affects the brain. It is caused by the over expression of proteins such as ephrin type-A receptor 2 (EphA2), epidermal growth factor receptor (EGFR) and EGFRvIII. These 3 protei...
作者:Singh Kh Dhanachandra , Sampath Bhuvaneshwari
来源:[J].Journal of biomolecular structure & dynamics, 2014, Vol.32 (5), pp.816-30PubMed
摘要:The existing H1N1 (2009) swine flu is pandemic in nature and is responsible for global economic losses and fatalities. Among the eight gene segments of H1N1, hemagglutinin (HA) plays a major role in the attachment of the virus to the host cell surface and entry of viral RNA into ...
作者:Singh Kh Dhanachandra , Kirubakaran Palani ...
来源:[J].International journal of computational biology and drug design, 2015, Vol.8 (1), pp.1-18PubMed
摘要:The main goal of this study is to understand the molecular-level interactions of neuraminidase inhibitor. The molecular docking, molecular dynamics and binding energy calculation analyses were carried out and the results revealed that the 150-cavitiy in the active site may play a...
作者:Nagamani Selvaraman , Singh Kh Dhanachandra , Muthusamy Karthikeyan
来源:[J].Meta gene, 2016, Vol.9, pp.26-36PubMed
摘要:FGF23, CYP24A1 and VDR altogether play a significant role in genetic susceptibility to chronic kidney disease (CKD). Identification of possible causative mutations may serve as therapeutic targets and diagnostic markers for CKD. Thus, we adopted both sequence and sequence-structu...
作者:Singh Kh Dhanachandra , Kirubakaran Palani ...
来源:[J].Journal of molecular modeling, 2012, Vol.18 (1), pp.39-51PubMed
摘要:To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV) fever. Hence, it is essential to identify drug candidates that could potentially impede CHIKV infection. Here, we present the development of a homology model of nsP2 protein ba...
作者:Singh Kh Dhanachandra , Naveena Queen , Karthikeyan Muthusamy
来源:[J].Molecular bioSystems, 2014, Vol.10 (8), pp.2146-59PubMed
摘要:A potent Jak2 inhibitor could solve numerous diseases including hypertension and cardiovascular diseases, myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, primary myelofibrosis, psoriasis and rheumatoid arthritis. So, identifying potent Jak2 inhibitors ...
作者:Singh Kh Dhanachandra , Karthikeyan Muthusamy
来源:[J].Journal of receptor and signal transduction research, 2014, Vol.34 (6), pp.513-26PubMed
摘要:The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure (BP). Mutations on the genes that encode components of the RAAS have played a significant role in genetic susceptibility to hypertension and have been intensively scrutinized. The...
作者:Singh Kh Dhanachandra , Nagamani Selvaraman
来源:[J].Journal of molecular modeling, 2013, Vol.19 (1), pp.407-19PubMed
摘要:Over expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) has been associated with leukemia, myeloma tumors and various other cancers. The function and regulatory mechanism of TOPK in tumor cells remains unclear. Structural studies that could reveal t...
作者:Singh Kh Dhanachandra , Chinnasamy Sathishkumar ...
来源:[J].Interdisciplinary sciences, computational life sciences, 2013, Vol.5 (2), pp.119-26PubMed
摘要:Alzheimer's disease is a progressive neurodegenerative disorder, which is characterized by amyloid β peptide deposition in the brain. Aβ peptide, the major component of amyloid plaques is generated by the sequential processing of a larger protein called amyloid Precursor Pro...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×