全部文献期刊会议图书|学者科研项目
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作者:Silvia Ribback , Andras Kiss ...
来源:[J].The American Journal of Pathology(IF 4.522), 2019, Vol.189 (5), pp.1077-1090
摘要:Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA doma...
作者:Silvia Ribback , Frank Dombrowski ...
来源:[J].The American Journal of Pathology(IF 4.522), 2018, Vol.188 (4), pp.995-1006
摘要:Primary liver cancer consists mainly of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). A subset of human HCCs expresses a ICC-like gene signature and is classified as ICC-like HCC. The Hippo pathway is a critical regulator of normal and malignant liver ...
作者:Silvia Ribback , Frank Dombrowski ...
来源:[J].Journal of Hepatology(IF 9.858), 2017
摘要:Background & Aims(#br)Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxal...
作者:Silvia Ribback , Kirsten Utpatel ...
来源:[J].Journal of Hepatology(IF 9.858), 2019, Vol.71 (4), pp.742-752
摘要:Background & Aims(#br)The ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is recognized as a tumor suppressor in many cancer types due to its ability to promote the degradation of numerous oncogenic target proteins. Herein, we aimed to elucidate its role in ...
作者:Silvia Ribback , Ralf Ewert
来源:[J].Clinical Neurology and Neurosurgery(IF 1.234), 2018, Vol.172, pp.93-95
摘要:Abstract(#br)In this case report we present an immunocompetent 64-year-old patient presenting with an orbitofrontal invasive aspergillosis treated successfully with voriconazole monotherapy following biopsy and orbital decompression.
作者:Silvia Ribback , Tetyana Yevsa ...
来源:[J].Gastroenterology(IF 12.821), 2016, Vol.151 (2), pp.338-350.e7
摘要:Background & Aims(#br)Even after potentially curative R0 resection, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis owing to high rates of local recurrence and metastasis to distant organs. However, we have no suitable transgenic animal models for...
作者:Silvia Ribback , Maria M. Simile ...
来源:[J].Journal of Hepatology(IF 9.858), 2016, Vol.64 (2), pp.333-341
摘要:Background & Aims(#br)Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver.(#br...
作者:Silvia Ribback , Frank Dombrowski ...
来源:[J].Journal of Hepatology(IF 9.858), 2016, Vol.64 (3), pp.618-627
摘要:Background & Aims(#br)Liver fibrosis is an increasing health concern worldwide and a major risk factor for hepatocellular carcinoma (HCC). Although the involvement of Hedgehog signaling in hepatic fibrosis has been known for some time, the causative role of activated Hedgeho...
作者:Silvia Ribback , Nils Kroeger ...
来源:[J].BBA - General Subjects(IF 3.848), 2020, Vol.1864 (7)
摘要:Abstract(#br)Backround(#br)Cytosolic glutaredoxin 2 (Grx2c) controls axonal outgrowth and is specifically induced in many cancer cell lines. We thus hypothesized that Grx2c promotes cell motility and invasiveness.(#br)Methods(#br)We characterized the impact of Grx2c expression in...
作者:Silvia Ribback , Frank Dombrowski ...
来源:[J].Experimental & Molecular Medicine(IF 2.573), 2018, Vol.50 (1), pp.e417-e417
摘要:Abstract(#br)Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 an...

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