全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Shivashankar Othy , Patrick Bruneval ...
来源:[J].Journal of Autoimmunity(IF 8.145), 2012, Vol.39 (3), pp.168-172Elsevier
摘要:Abstract(#br)Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasi...
作者:Shivashankar Othy , Selma Topçu ...
来源:[J].European Journal of Immunology(IF 4.97), 2014, Vol.44 (7), pp.2059-2063Wiley
摘要:Several mechanisms account for the beneficial effect of intravenous immunoglobulin (IVIg) in autoimmune and inflammatory diseases. These mechanisms include effects on the cellular compartment and on the humoral compartment. Thus, IVIg impacts on dendritic cells, macrophages,...
作者:Shivashankar Othy , Pushpa Hegde ...
来源:[J].Journal of Clinical Immunology(IF 3.382), 2010, Vol.30 (1), pp.4-8Springer
摘要:Abstract(#br)An altered immune homeostasis as a result of deficiency or defective function of CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) is common in several autoimmune diseases. Hence, therapeutic strategies to render Tregs functionally competent are being investigated. Int...
作者:Shivashankar Othy , Milton L Greenberg ...
来源:[J].eLife, 2017, Vol.6eLife科学出版社
摘要:Ca2+ influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency...
作者:Shivashankar Othy , Amit Jairaman ...
来源:[J].eLife, 2017, Vol.6eLife科学出版社
摘要:Calcium is an essential cellular messenger that regulates numerous functions in living organisms. Here, we describe development and characterization of ‘Salsa6f’, a fusion of GCaMP6f and tdTomato optimized for cell tracking while monitoring cytosolic Ca2+, and a t...

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