全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Shinya Akatsuka , Yoriko Yamashita ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (8)DOAJ
摘要:Iron overload has been associated with carcinogenesis in humans. Intraperitoneal administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated trea...
作者:Shinya Akatsuka , Kanako Shinjo ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (3)DOAJ
摘要:Clear cell adenocarcinoma of the ovary (OCC) is a chemo-resistant tumor with a relatively poor prognosis and is frequently associated with endometriosis. Although it is assumed that oxidative stress plays some role in the malignant transformation of this tumor, the characteristic...
作者:... Kyoko Yamashita , Yasumasa Okazaki , Shinya Akatsuka
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2017, Vol.108, pp.610-626Elsevier
摘要:Abstract(#br)Epidemiological data indicate a constant worldwide increase in cancer mortality, although the age of onset is increasing. Recent accumulation of genomic data on human cancer via next-generation sequencing confirmed that cancer is a disease of genome alteration. In ma...
作者:Shinya Akatsuka , Shenqi Wang ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2017, Vol.106, pp.91-99Elsevier
摘要:Abstract(#br)CD44 exists as a standard ( CD44s ) isoform and different variant isoforms ( CD44v ) due to alternative splicing. While the complex nature of these different isoforms has not been fully elucidated, CD44v expression has been shown to exert oncogenic effects by promoti...
作者:Shinya Akatsuka , Takashi Takahashi ...
来源:[J].Fertility and Sterility(IF 4.174), 2012, Vol.98 (2), pp.415-422.e12Elsevier
摘要:Objective(#br)To understand the role of ectopic endometriotic stromal cells in ovarian endometriosis (OEM) and the associated risks for infertility and carcinogenesis.(#br)Design(#br)Analyses of secreted proteins and gene expression using immortalized eutopic/ectopic endomet...
作者:Shinya Akatsuka , Guang Hua Li , Shinya Toyokuni
来源:[J].Free Radical Research(IF 3.279), 2018, Vol.52 (11-12), pp.1323-1327Taylor & Francis
摘要:Abstract(#br)Evolution of the species and carcinogenesis are similar in that genomic alterations are the key events. Oxidative stress derived from various etiologies is one of the major causes of carcinogenesis by inducing mutations in the genome. Persistent oxidative stress in t...
作者:Shinya Akatsuka , Than Tin Aung ...
来源:[J].The American Journal of Pathology(IF 4.522), 2006, Vol.169 (4), pp.1328-1342Elsevier
摘要:Oxidative stress is a persistent threat to the genome and is associated with major causes of human mortality, including cancer, atherosclerosis, and aging. Here we established a method to generate libraries of genomic DNA fragments containing oxidatively modified bases by using s...

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