全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Shin-Ichi Nishikawa , Shin Kawamata
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (5)DOAJ
摘要:Human induced pluripotent stem cells (hiPSCs) possess the capabilities of self-renewal and differentiation into multiple cell types, and they are free of the ethical problems associated with human embryonic stem cells (hESCs). These characteristics make hiPSCs a promising ch...
作者:... Kenichiro Kobayashi , Shin-Ichi Nishikawa , Teruo Akuta
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (2)DOAJ
摘要:Vitrification and slow-freezing methods have been used for the cryopreservation of human pluripotent stem cells (hPSCs). Vitrification requires considerable skill and post-thaw recovery is low. Furthermore, it is not suitable for cryopreservation of large numbers of hPSCs. W...
作者:Yan-Fung Wong , Lars Martin Jakt , Shin-Ichi Nishikawa
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)DOAJ
摘要:Treatment with the demethylating drugs 5-azacytidine (AZA) and decitabine (DAC) is now recognised as an effective therapy for patients with Myelodysplastic Syndromes (MDS), a range of disorders arising in clones of hematopoietic progenitor cells. A variety of cell models have bee...
作者:Shin-Ichi Nishikawa , Akiyoshi Uemura
来源:[J].Cancer Cell(IF 24.755), 2014, Vol.25 (1), pp.102-117Elsevier
摘要:Summary(#br)Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho GTPase, during tumor progression. RhoJ blockade provides a double assault on tumo...
作者:... Yosuke Tanaka , Shin-Ichi Nishikawa , Hiroshi Kataoka
来源:[J].Experimental Hematology(IF 2.907), 2012, Vol.40 (9), pp.738-750.e11Elsevier
摘要:Etv2 is a master gene for the commitment of hematopoietic/endothelial cells and is a potent inducer of endothelial/hematopoietic cells from embryonic stem cells. Etv2 is highly expressed in endothelial/hematopoietic precursors but is downregulated when they are differentiated, in...
作者:... Guo Ding , Yosuke Tanaka , Shin-Ichi Nishikawa
来源:[J].Experimental Hematology(IF 2.907), 2013, Vol.41 (6), pp.567-581.e9Elsevier
摘要:Hematopoietic cells (HPCs) develop from hemogenic endothelial cells (ECs), a specialized type of ECs undergoing hematopoietic transition. However, the mesoderm origin for hemogenic ECs or HPCs has not been clarified. To examine the origin for hemogenic mesoderm, we inactivated Et...
作者:Shin-Ichi Nishikawa , Hiroshi Tarui
来源:[J].Protein Expression and Purification(IF 1.429), 2013, Vol.90 (1), pp.20-26Elsevier
摘要:Abstract(#br)Leukemia inhibitor factor (LIF) is a three disulfide bridge-containing cytokine with numerous regulatory effects. In this report, we present the high level expression of a soluble recombinant human LIF (rhLIF) in Escherichia coli . A codon-optimized Profinity eX...
作者:Shin-Ichi Nishikawa , Satomi Nishikawa ...
来源:[J].Cytokine and Growth Factor Reviews(IF 8.831), 1998, Vol.9 (3), pp.213-220Elsevier
摘要:Abstract(#br)Gene-knock-out studies implicate roles of lymphotoxin (LT) α β and LT β R in the initial phase of Peyers patch (PP) organogenesis. We recently identified the requirement of IL-7R α / γ c/Jak3 signal in LT α β production of IL-7R α + cells. These observation...

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