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作者:Shawn J. Szyjka , Christopher J. Viggiani , Oscar M. Aparicio
来源:[J].Molecular Cell(IF 15.28), 2005, Vol.19 (5), pp.691-697Elsevier
摘要:Summary(#br)Mrc1 associates with replication forks, where it transmits replication stress signals and is required for normal replisome pausing in response to nucleotide depletion. Mrc1 also plays a poorly understood role in DNA replication, which appears distinct from its ro...
作者:Shawn J. Szyjka , Ewa T. Lis ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2007, Vol.104 (22), pp.9290-9295JSTOR
摘要:Activation of the checkpoint kinase Rad53 is a critical response to DNA damage that results in stabilization of stalled replication forks, inhibition of late-origin initiation, up-regulation of dNTP levels, and delayed entry to mitosis. Activation of Rad53 is well understood and ...

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