全部文献期刊会议图书|学者科研项目
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作者:... Poonam Goswami , Sharad Sharma , Sarika Singh
来源:[J].Cellular Signalling(IF 4.304), 2018, Vol.42, pp.211-226
摘要:Abstract(#br)The present study was conducted to correlate the cellular and molecular alterations in Alzheimer's pathology employing streptozotocin (STZ) induced experimental rat model. The STZ was administered in rat brain bilaterally by intracerebroventricular route using stereo...
作者:Varun Ahuja , Sanjay Bokan , Sharad Sharma
来源:[J].Drug Discovery Today(IF 6.551), 2017, Vol.22 (1), pp.127-132
摘要:The sensitivity of the various preclinical models used to predict toxicity in humans varies. In this review, we analyze the various models used to predict safety in drug discovery and development with a view to understanding their translational value in humans. Twenty recently ap...
作者:... Neeraj Joshi , Sharad Sharma , Sarika Singh
来源:[J].Environmental Toxicology and Pharmacology(IF 2.005), 2015, Vol.40 (1), pp.122-139
摘要:Abstract(#br)The present study was conducted to investigate the effect of rotenone on astrocytes activation, their viability and its effect on neuronal death in different brain regions. Rotenone was injected in rat brain by intracerebroventricularly (bilateral) route at dose...
作者:Sharad Sharma , C. Nath
来源:[J].Mutation Research - Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 2015, Vol.778, pp.22-36
摘要:Abstract(#br)The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h...
作者:... Sadan Kumar , Sharad Sharma , Srikanta Kumar Rath
来源:[J].DARU Journal of Pharmaceutical Sciences, 2019, Vol.27 (1), pp.219-231
摘要:Abstract(#br) Background(#br)Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Due to the unavailability of detailed toxicological studies on DEGEE, the ...
作者:Sharad Sharma , Hang-Ping Yao ...
来源:[J].Molecular Oncology(IF 6.701), 2014, Vol.8 (3), pp.469-482
摘要:Abstract(#br)Targeted inhibition of MET/RON signaling by tyrosine kinase inhibitor BMS-777607 for cancer treatment is currently under clinical trials. We have previously shown that BMS-777607 induces chemoresistance in vitro by causing polyploidy, which hampers therapeutic e...
作者:Sharad Sharma , Arvind K. Srivastava
来源:[J].Experimental and Toxicologic Pathology(IF 2.622), 2014, Vol.66 (7), pp.281-291
摘要:Abstract(#br)The beneficial effects of hydroethanol extract of Symplocos cochinchinensis (SCE) has been explored against hyperglycemia associated secondary complications in streptozotocin induced diabetic rat model. The experimental groups consist of normal control (NC), dia...
作者:Sharad Sharma , Manish Rana ...
来源:[J].Environmental Toxicology and Pharmacology(IF 2.005), 2004, Vol.18 (1), pp.1-7
摘要:Abstract(#br)The effect of pulp and paper-mill effluents on terrestrial animals was investigated using male albino rats as a test organism, under controlled laboratory conditions. Effluent consumption for 15 days caused a reduction in the relative weight of the testis (mg/10...

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