全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Huanhuan Liu , Shaoxiong Liang , Jianping Wen
来源:[J].Journal of Industrial Microbiology & Biotechnology(IF 2.321), 2017, Vol.44 (11), pp.1527-1540
摘要:Tacrolimus is widely used as an immunosuppressant in the treatment of various autoimmune diseases. However, the low fermentation yield of tacrolimus has thus far restricted its industrial applications. To solve this problem, the time-series response mechanisms of the intracellula...
作者:... Cheng Wang , Shaoxiong Liang , Jianping Wen
来源:[J].Microbial Cell Factories(IF 3.306), 2017, Vol.16 (1)
摘要:Nonomuraea dietziae is a promising microorganism to mediate the region-specific monooxygenation reaction of cyclosporine A (CsA). The main product [(4′-OH)MeLeu]4-CsA possesses high anti-HIV/HCV and hair growth-stimulating activities while avoiding the immunosuppr...
作者:Shaoxiong Liang , Huanhuan Liu ...
来源:[J].Bioresource Technology(IF 4.75), 2018, Vol.267, pp.599-607
摘要:Abstract(#br)In this study, the engineered E. coli was constructed for efficient transformation of glycerol to 1,3-propanediol (1,3-PDO). To regenerate NADPH, the key bottleneck in 1,3-PDO production, heterologous NADP + -dependent glyceraldehyde-3-phosphate dehydrogenase (G...
作者:Shaoxiong Liang , Laurent Guillaumat , Papa-Birame Gning
来源:[J].International Journal of Impact Engineering(IF 1.681), 2015, Vol.80, pp.56-64
摘要:Abstract(#br)This paper presents an experimental investigation of the impact behaviour of flax/epoxy composite plates submitted to low-velocity transverse impact. Low energy drop-weight impact tests have been performed on two types of quasi-isotropic flax/epoxy composites, r...
作者:Shaoxiong Liang , Papa-Birame Gning , Laurent Guillaumat
来源:[J].International Journal of Fatigue(IF 1.976), 2014, Vol.63, pp.36-45
摘要:Abstract(#br)The tension–tension fatigue behaviour of flax fibre reinforced epoxy matrix composites have been investigated for specimens having [0] 12 , [90] 12 , [0/90] 3S and [±45] 3S lay-ups. The Probabilized Stress–Number of cycles (P-S–N) curves have been determine...
作者:Shaoxiong Liang , Papa-Birame Gning , Laurent Guillaumat
来源:[J].Materials and Design(IF 2.913), 2015, Vol.67, pp.344-353
摘要:Abstract(#br)Experimental investigations were conducted on flax and E-glass fibres reinforced epoxy matrix composites subjected to quasi-static loadings. Flax/epoxy samples having [0] 12 , [90] 12 , [0/90] 3S and [±45] 3S stacking sequences, with a fibre volume fraction of 4...
作者:Shaoxiong Liang , Dacheng Gao ...
来源:[J].Journal of Industrial Microbiology & Biotechnology(IF 2.321), 2018, Vol.45 (8), pp.681-696
摘要:Abstract(#br)As an important feedstock monomer for the production of biodegradable stereo-complex poly-lactic acid polymer, d -lactate has attracted much attention. To improve d -lactate production by microorganisms such as Lactobacillus delbrueckii , various fermentation co...
作者:Shaoxiong Liang , Junhua Wang ...
来源:[J].Bioprocess and Biosystems Engineering(IF 1.869), 2019, Vol.42 (7), pp.1081-1098
摘要:Abstract(#br)Tacrolimus has been widely used as a powerful novel immunosuppressant. The objective of this study was to improve the production of tacrolimus by engineering the target genes of important primary and secondary metabolic pathways and feeding exogenous precursors. Base...
作者:Shaoxiong Liang , Huanhuan Liu
来源:[J].Applied Microbiology and Biotechnology(IF 3.689), 2019, Vol.103 (16), pp.6629-6644
摘要:Abstract(#br)Bleomycin, a broad-spectrum antibiotic, has been widely used for various tumor treatments. However, its poor fermentation yield is not satisfactory for industrial production. Here, the ArsR/SmtB family regulator BlmR was characterized as a repressor of bleomycin prod...
作者:Cheng Wang , Di Huang , Shaoxiong Liang
来源:[J].Applied Microbiology and Biotechnology(IF 3.689), 2018, Vol.102 (17), pp.7541-7553
摘要:Abstract(#br)Tacrolimus is a widely used immunosuppressive agent in the treatment of various clinical diseases. However, the low fermentation yield seriously limits its further application. To stimulate tacrolimus synthesis, nine chemical elicitors of five groups were evaluated f...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×