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作者:Selvaraman Nagamani , Karthikeyan Muthusamy
来源:[J].Pharmaceutical Research(IF 4.742), 2017, Vol.34 (7), pp.1444-1458Springer
摘要:Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to influence ABCC2 expression but its exact molecular mechanism is unknown...
作者:Karthikeyan Muthusamy , Selvaraman Nagamani
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2018, Vol.81, pp.14-24Elsevier
摘要:Abstract(#br)Pharmacogenetics and pharmacogenomics have become presumptive with advancements in next-generation sequencing technology. In complex diseases, distinguishing the feasibility of pathogenic and neutral disease-causing variants is a time consuming and expensive pro...
作者:Selvaraman Nagamani , Karunakar Tanneeru ...
来源:[J].Journal of Biomedical Informatics(IF 2.131), 2018, Vol.85, pp.114-125Elsevier
摘要:Abstract(#br)Molecular Property Diagnostic Suite - Diabetes Mellitus (MPDS DM ) is a Galaxy-based, open source disease-specific web portal for diabetes. It consists of three modules namely (i) data library (ii) data processing and (iii) data analysis tools. The data library ...
作者:Selvaraman Nagamani , Karthikeyan Muthusamy ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (9), pp.2169-2180Springer
摘要:Abstract(#br)Biotin carboxylase (AccC) protein plays an essential role in cell wall biosynthesis in majority of bacterial genera. Inhibition of cell wall biosynthesis might be an ideal way to control the bacterial multiplication in the host system. AccC is one of the promisi...
作者:... Karthikeyan Muthusamy , Kh. Dhanachandra Singh , Selvaraman Nagamani
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (8), pp.2105-2116Springer
摘要:Abstract(#br)Carbamate kinase catalyzes the reversible reaction of carbamoyl phosphate, ADP to ATP and ammonium phosphate which is then hydrolyzed to ammonia and carbonate. In this study, the three-dimensional model of TvCK has been constructed by molecular modeling studies....
作者:... Karthikeyan Muthusamy , Kh. Dhanachandra Singh , Selvaraman Nagamani
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (8), pp.3812-3822Springer
摘要:Abstract(#br)The 3-phosphoinositide-dependent protein kinase-1 (PDK1) is an imminent target for discovering novel anticancer drugs. In order to understand the structure–activity correlation of naphthyridine-based PDK-1 inhibitors, we have carried out a combined pharmacophore...
作者:... Muthusamy Karthikeyan , Palani Kirubakaran , Selvaraman Nagamani
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2011, Vol.30, pp.186-197Elsevier
摘要:Abstract(#br)Janus kinase 2 (JAK2) plays a crucial role in the patho-mechanism of cardiovascular pathologies, myeloproliferative disorders and many other diseases. Thus, effective JAK2 kinase inhibitors may be of significant therapeutic importance. In this study, a pharmacophore ...
作者:... Kh. Dhanachandra Singh , Selvaraman Nagamani , Kumpati Premkumar
来源:[J].Journal of Molecular Modeling(IF 1.984), 2013, Vol.19 (1), pp.407-419Springer
摘要:Abstract(#br)Over expression of T-lymphokine–activated killer cell–originated protein kinase (TOPK) has been associated with leukemia, myeloma tumors and various other cancers. The function and regulatory mechanism of TOPK in tumor cells remains unclear. Structural studies t...
作者:Selvaraman Nagamani , Karthikeyan Muthusamy
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (10)PLOS
摘要:The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1). Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy. Chronic kidney disease (CKD) patients are commonly...
作者:Selvaraman Nagamani , Chandrasekhar Kesavan , Karthikeyan Muthusamy
来源:[J].Combinatorial Chemistry & High Throughput Screening(IF 2), 2018, Vol.21 (5), pp.329-343Bentham
摘要:Aim and Objective: Vitamin D3 (1,25(OH)2D3) is a biologically active metabolite andplays a wide variety of regulatory functions in human systems. Currently, several Vitamin Danalogues have been synthesized and tested against VDR (Vitamin D Receptor). Electrostaticpotential method...

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