全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Jirong Yue , Sean X. Leng , Birong Dong
来源:[J].BMC Medical Genetics(IF 2.536), 2017, Vol.18 (1)Springer
摘要:Recent evidence indicates that ataxia telangiectasia mutated (ATM) is a cytoplasmic protein that involves in insulin signaling pathways. When ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Up to ...
作者:Sean X. Leng , Jeremy Kamil ...
来源:[J].GeroScience, 2017, Vol.39 (3), pp.251-259Springer
摘要:Human cytomegalovirus (CMV) is one of the largest viruses known to cause human diseases. Chronic CMV infection, as defined by anti-CMV IgG serology, increases with age and is highly prevalent in older adults. It has complex biology with significant immunologic and health conseque...
作者:Yiyin Chen , Sally Liu , Sean X. Leng
来源:[J].Clinical Therapeutics(IF 2.23), 2019, Vol.41 (3), pp.400-409Elsevier
摘要:Abstract(#br)Purpose(#br)The aim was to provide an overview of chronic low-grade inflammatory phenotype (CLIP) and evidence for its role in the pathogenesis of frailty and other chronic conditions as well as potential causative factors and interventions.(#br)Methods(#br)We r...
作者:... Zheng Chen , Sean X. Leng , Daria Maria Monti
来源:[J].Oxidative Medicine and Cellular Longevity(IF 3.393), 2018, Vol.2018Hindawi
摘要:Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD), and a substantial portion of elderly population at risk of these dise...
作者:Sean X. Leng , Jing Yan
来源:[J].Oxidative Medicine and Cellular Longevity(IF 3.393), 2019, Vol.2019Hindawi
摘要:Calorie restriction (CR) is a nongenetic intervention with a robust effect on delaying aging in mammals and other organisms. A mild stimulation on mitochondrial biogenesis induced by CR seems to be an important action mode for its benefits. Here, we reported that a component...
作者:... Jeremy D. Walston , Rebeca Rios , Sean X. Leng
来源:[J].Vaccine(IF 3.492), 2018, Vol.36 (16), pp.2220-2225Elsevier
摘要:Abstract(#br)Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, co...
作者:Juliette Tavenier , Joseph B. Margolick , Sean X. Leng
来源:[J].Medical Microbiology and Immunology(IF 3.545), 2019, Vol.208 (3-4), pp.289-294Springer
摘要:Abstract(#br)Both aging and treated human immunodeficiency virus (HIV) infection are characterized by low-level chronic inflammation and immune activation which contribute to the development of age-related diseases, frailty, and early mortality. Chronic cytomegalovirus (CMV) infe...
作者:... Peisong Gao , Maolong Gao , Sean X. Leng
来源:[J].Molecular Neurobiology(IF 5.471), 2019, Vol.56 (11), pp.7664-7679Springer
摘要:Abstract(#br)α-Synuclein (α-syn), a metabolite of neurons, induces glial activation and neuroinflammation and participates in pathogenesis of neurodegenerative diseases. This inflammatory response involves activation of toll-like receptors (TLRs) and its neurotoxic outcomes ...

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