全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Scott J D , Stofko R E ...
来源:[J].The Journal of biological chemistry(IF 4.651), 1990, Vol.265 (35), pp.21561-6PubMed
摘要:The type II cAMP-dependent protein kinase (PKA) is localized to specific subcellular environments through binding of dimeric regulatory subunits (RII) to anchoring proteins. Cytoskeletal localization occurs through RII dimer interaction with the PKA substrate molecule microtubule...
作者:Scott J D
来源:[J].CMAJ(IF 6.465), 1999, Vol.161 (9), pp.1102, 1104PubMed
作者:Scott J D , Cadd G G ...
来源:[J].Biology of reproduction(IF 4.027), 1990, Vol.43 (1), pp.46-54PubMed
摘要:Cyclic AMP (cAMP) and cAMP-dependent protein kinases (PKAs) are believed to be involved in the regulation of essential spermatozoal functions, such as motility, epididymal maturation, capacitation, and the acrosome reaction. In this study, we document the presence of significant ...
作者:Scott J D , Wang H Y
来源:[J].Journal of Biological Chemistry(IF 4.651), 1999, Vol.274 (3), pp.1588-95PubMed
摘要:Signals mediated by G-protein-linked receptors display agonist-induced attenuation and recovery involving both protein kinases and phosphatases. The role of protein kinases and phosphatases in agonist-induced attenuation and recovery of beta-adrenergic receptors was explored by t...
作者:... Lepine A J , Scott J D , Murphy K E
来源:[J].Journal of Heredity(IF 1.995), 1999, Vol.90 (1), pp.99-103PubMed
摘要:Canine hip dysplasia is a heritable developmental disease resulting, in part, from increased laxity in hip joints and is a precursor to degenerative joint disease. Identification of genetic markers linked to joint laxity would foster development of more accurate diagnostic method...
作者:... Faux M C , Scott J D , Newton A C
来源:[J].Journal of Biological Chemistry(IF 4.651), 1999, Vol.274 (10), pp.6461-8PubMed
摘要:Protein kinase C is processed by three phosphorylation events before it is competent to respond to second messengers. Specifically, the enzyme is first phosphorylated at the activation loop by another kinase, followed by two ordered autophosphorylations at the carboxyl terminus (...
作者:... Taylor S S , Scott J D , Korsmeyer S J
来源:[J].Molecular Cell(IF 15.28), 1999, Vol.3 (4), pp.413-22PubMed
摘要:Signaling pathways between cell surface receptors and the BCL-2 family of proteins regulate cell death. Survival factors induce the phosphorylation and inactivation of BAD, a proapoptotic member. Purification of BAD kinase(s) identified membrane-based cAMP-dependent protein kinas...

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