全部文献期刊会议图书|学者科研项目
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作者:Savina Apolloni , Cinzia Volonté
来源:[J].Frontiers in Cellular Neuroscience(IF 4.469), 2017, Vol.11DOAJ
摘要:Autophagy and inflammation play determinant roles in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), an adult-onset neurodegenerative disease characterized by deterioration and final loss of upper and lower motor neurons (MN) priming microglia to sustain neuroinflammatio...
作者:Savina Apolloni , Paola Fabbrizio ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2016, Vol.13 (1)Springer
摘要:Abstract(#br) Background(#br)Amyotrophic lateral sclerosis (ALS) is a disease with a strong neuroinflammatory component sustained by activated microglia contributing to motoneuron death. However, how to successfully balance neuroprotective versus neurotoxic actions by the use of ...
作者:Savina Apolloni , Susanna Amadio ...
来源:[J].Disease Models & Mechanisms(IF 4.959), 2014, Vol.7 (9), pp.1101-1109DOAJ
摘要:In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracellular ATP, in modulating physiopathological mechanisms in the central nervous system. In particular, P2X7 has been shown to be implicated in neuropsychiatry, chronic pain, neur...
作者:Savina Apolloni , Andrea Bianchi ...
来源:[J].Brain Pathology(IF 4.739), 2020, Vol.30 (2), pp.272-282Wiley
摘要:Abstract(#br)Muscle weakness plays an important role in neuromuscular disorders comprising amyotrophic lateral sclerosis (ALS). However, it is not established whether muscle denervation originates from the motor neurons, the muscles or more likely both. Previous studies have...
作者:... Eleonora Aronica , Caterina Bendotti , Savina Apolloni
来源:[J].Mediators of Inflammation(IF 3.882), 2017, Vol.2017Hindawi
摘要:Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNF α is one of the major players governing the inflammation in t...
作者:... Susanna Amadio , Paola Fabbrizio , Savina Apolloni
来源:[J].Seminars in Cell and Developmental Biology(IF 6.202), 2019, Vol.94, pp.121-128Elsevier
摘要:Abstract(#br)Today neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not...
作者:Cinzia Volonté , Savina Apolloni , Mario Sabatelli
来源:[J].Pharmacology and Therapeutics(IF 7.793), 2019, Vol.202, pp.120-131Elsevier
摘要:Abstract(#br)ALS currently remains a challenge despite many efforts in performing successful clinical trials and formulating therapeutic solutions. By learning from current failures and striving for success, scientists and clinicians are checking every possibility to search for m...
作者:Giacomo Giacovazzo , Savina Apolloni , Roberto Coccurello
来源:[J].Purinergic Signalling(IF 2.635), 2018, Vol.14 (3), pp.299-305Springer
摘要:Abstract(#br)The established role of ATP-responsive P2X7 receptor in inflammatory, neurodegenerative, and immune diseases is now expanding to include several aspects of metabolic dysregulation. Indeed, P2X7 receptors are involved in β cell function, insulin secretion, and li...
作者:Savina Apolloni , Chiara Parisi
来源:[J].Neuropharmacology(IF 4.114), 2016, Vol.104, pp.180-193Elsevier
摘要:Abstract(#br)By signalling through purinergic receptors classified as ionotropic P2X (for ATP) and metabotropic P1 (for adenosine) and P2Y (mainly for ADP, UDP, UTP, ATP), the extracellular nucleotides and their metabolic derivatives originated by extracellular activity of s...
作者:Savina Apolloni , Paola Fabbrizio ...
来源:[J].Molecular Neurobiology(IF 5.471), 2016, Vol.53 (1), pp.518-531Springer
摘要:Abstract(#br)Mutations in the Cu2+/Zn2+ superoxide dismutase 1 (SOD1) gene underlie 14–23 % of familial and 1–7 % of sporadic cases of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease characterized by a specific loss of motor...

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