全部文献期刊会议图书|学者科研项目
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作者:Sarah M. Dunlap , Stephen D. Hursting
来源:[J].Cancer Biology & Therapy(IF 3.287), 2013, Vol.14 (4), pp.357-364
摘要:Obesity is associated with increased breast tumor aggressiveness and decreased response to multiple modalities of therapy in postmenopausal women. Delivering cancer chemotherapeutic drugs using nanoparticles has evolved as a promising approach to improve the efficacy of anticance...
作者:Sarah M. Dunlap , Audrey J. Rasmussen ...
来源:[J].Cancer & Metabolism, 2016, Vol.4 (1)
摘要:Abstract(#br) Background(#br)Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimens. While the beneficial effects of CR...
作者:Stephen D. Hursting , Sarah M. Dunlap
来源:[J].Annals of the New York Academy of Sciences(IF 4.375), 2012, Vol.1271 (1), pp.82-87
摘要:Obesity is an established risk and progression factor for many cancers. In the United States more than one‐third of adults, and nearly one in five children, are currently obese. Thus, a better understanding of the mechanistic links between obesity and cancer is urgently need...
作者:Sarah M. Dunlap , Karrie E. Wheatley
来源:[J].PLOS ONE(IF 3.73), 2013, Vol.8 (6)
摘要:Obesity, prevalent in >35% of US women, is an established risk and progression factor for postmenopausal breast cancer, and strategies to break the obesity-breast cancer link are urgently needed. Approximately 30% of breast cancers carry p53 tumor suppressor gene alterations...
作者:Sarah M. Dunlap , Valerie B. Holcomb
来源:[J].Alcoholism: Clinical and Experimental Research(IF 3.421), 2012, Vol.36 (4), pp.577-587
摘要:Background: Alcohol consumption is an established risk factor for breast cancer. Yet, the mechanism by which alcohol affects breast cancer development remains unresolved. The transition from the premenopausal to the postmenopausal phase is associated with a drastic reduction...
作者:Sarah M. Dunlap , Joseph Celestino ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2007, Vol.104 (28), pp.11736-11741
摘要:Overexpression of insulin-like growth factor binding protein 2 (IGFBP2) is associated with progression in many types of human cancer. In this study we used a glial-specific transgenic mouse model to examine the active role of IGFBP2 in tumorigenesis and progression. Our stud...
作者:Sarah M. Dunlap , Yuexin Liu ...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2012, Vol.109 (9), pp.3475-3480
摘要:Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing the IGFBP2 network, combining transcriptional profiling ...
作者:Sarah M. Dunlap , Jennifer Huang ...
来源:[J].Diabetes(IF 7.895), 2015, Vol.64 (5), pp.1632-1642
摘要:Metformin treatment is associated with a decreased risk and better prognosis of pancreatic cancer (PC) in patients with type 2 diabetes, but the mechanism of metformin’s PC growth inhibition in the context of a prediabetic state is unknown. We used a Panc02 pancreatic tumor ...
作者:Sarah M. Dunlap , Marcie J. Hursting
来源:[B].Energy Balance and Cancer2013
摘要:Abstract Calorie restriction (CR) is one of the most potent, broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned from research on CR to cancer prevention strategies in human...

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