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作者:Sarah Lazzaro , Sumathy Mathialagan ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.787-796Springer
摘要:Transporter-mediated hepatic uptake is proven to be the rate-determining step in the systemic clearance of several drugs. Therefore, accurate measurement of active and passive uptake clearances in vitro is critical to facilitate pharmacokinetics and drug-drug interaction pre...
作者:Sarah Lazzaro , Soraya Eatemadpour ...
来源:[J].CPT: Pharmacometrics & Systems Pharmacology, 2019, Vol.8 (9), pp.634-642Wiley
摘要:Physiologically‐based pharmacokinetic ( PBPK ) modeling is a powerful tool to quantitatively describe drug disposition profiles in vivo , thereby providing an alternative to predict drug–drug interactions ( DDI s) that have not been tested clinically. This study aimed to pre...

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