全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Santosh Philips , Heng-Yi Wu , Lang Li
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (11)Springer
摘要:With the explosion of data comes a proportional opportunity to identify novel knowledge with the potential for application in targeted therapies. In spite of this huge amounts of data, the solutions to treating complex disease is elusive. One reason being that these diseases are ...
作者:Santosh Philips , Jing Zhou ...
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (S7)Springer
摘要:Abstract(#br) Introduction(#br)One major challenge in personalized medicine research is to identify the environmental factors that can alter drug response, and to investigate their molecular mechanisms. These environmental factors include co-medications, food, and nutrition or di...
作者:Santosh Philips , Mark Powell ...
来源:[J].BMC Cancer(IF 3.333), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinic...
作者:Santosh Philips , Anna M. Storniolo ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2015, Vol.154 (2), pp.263-273Springer
摘要:Abstract(#br)Adjuvant therapy for hormone receptor (HR) positive postmenopausal breast cancer patients includes aromatase inhibitors (AI). While both the non-steroidal AI letrozole and the steroidal AI exemestane decrease serum estrogen concentrations, there is evidence that...
作者:Santosh Philips , Janet S. Carpenter ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2013, Vol.138 (3), pp.807-816Springer
摘要:Abstract(#br)Up to 25 % of patients discontinue adjuvant aromatase inhibitor (AI) therapy due to intolerable symptoms. Predictors of which patients will be unable to tolerate these medications have not been defined. We hypothesized that inherited variants in candidate genes ...
作者:Santosh Philips , Anne T. Nguyen ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2009, Vol.117 (3), pp.571-575Springer
摘要:Abstract(#br)Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. We collected hot flash fre...
作者:Santosh Philips , Todd C. Skaar ...
来源:[J].American Journal of Obstetrics and Gynecology(IF 3.877), 2013, Vol.208 (3), pp.215.e1-215.e6Elsevier
摘要:Objective(#br)We previously demonstrated that maternal and fetal genotypes are associated independently with neonatal respiratory distress syndrome. The objective of the current study was to determine the impact of maternal and fetal single-nucleotide polymorphisms (SNPs) in...
作者:Santosh Philips , Catherine L. McCormick ...
来源:[J].American Journal of Obstetrics and Gynecology(IF 3.877), 2012, Vol.206 (5), pp.447.e17-447.e24Elsevier
摘要:Objective(#br)To determine the impact of maternal and fetal single nucleotide polymorphisms in key betamethasone pathways on neonatal outcomes.(#br)Study Design(#br)DNA was obtained from women given betamethasone and their infants. Samples were genotyped for 73 exploratory d...
作者:Santosh Philips , Heng-Yi Wu , Lang Li
来源:[J].2017, Vol.18 (11), pp.397BMC
摘要:With the explosion of data comes a proportional opportunity to identify novel knowledge with the potential for application in targeted therapies. In spite of this huge amounts of data, the solutions to treating complex disease is elusive. One reason being that these diseases are ...

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