全部文献期刊会议图书|学者科研项目
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作者:Sachdeva M , Dole V S ...
来源:[J].The American journal of tropical medicine and hygiene(IF 2.534), 2001, Vol.65 (5), pp.573-82PubMed
摘要:We present a new polymerase chain reaction assay based on telomeric sequences of Leishmania donovani. When this assay was used in dilutions of purified L. donovani DNA, a strong amplification signal was observed with 1 fg of DNA. In a specificity test that used purified DNA from ...
作者:Kapoor P , Sachdeva M , Madhubala R
来源:[J].FEMS microbiology letters(IF 2.049), 1999, Vol.176 (2), pp.429-35PubMed
摘要:Taxol, a mitotic spindle toxin, was found to selectively inhibit the proliferation of Leishmania donovani in vitro at nanomolar concentrations with an IC50 of 35 nM. Concentrations of taxol as high as 50 nM, however, did not affect J774A.1 murine macrophages. Taxol (30 nM) also i...
作者:Sachdeva M , Sande E R
来源:[J].Antimicrobial agents and chemotherapy(IF 4.565), 1994, Vol.38 (5), pp.1186-9PubMed
摘要:Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased a...
作者:Sharma K , Khan AD , Sachdeva M
来源:[J].Journal of Applied Pharmaceutical Sciences and Research, 2018, Vol.1 (1)JAPSR
摘要:Introduction: The oral transmucosal Timolol maleate delivery bypasses liver and avoids presystemic elimination in the gastro intestinal tract and liver which enhance the bioavailability as well decreases the adverse effect. Objective: The present investigation highlights the...
作者:Mishra S* , Sachdeva M , Sara U V S
来源:[J].Inventi Rapid NDDS, 2013, Vol.2013Inventi
摘要:In the past few decades, considerable attention has been made on the discovery and development of novel drug delivery system (NDDS). Different types of pharmaceutical carriers such as particulate, polymeric, macromolecular and cellular vesicles are discovered. Out of them, vesicl...
作者:Sachdeva M , Sachdeva N ...
来源:[J].Cancer gene therapy, 2015, Vol.22 (11), pp.509-17PubMed
摘要:Although varied drugs and therapies have been developed for lung cancer treatment, in the past 5 years overall survival rates have not improved much. It has also been reported that lung cancer is diagnosed in most of the patients when it is already in the advanced stages with het...
作者:Sachdeva M , Wu H ...
来源:[J].Oncogene, 2011, Vol.30 (7), pp.822-31PubMed
摘要:MicroRNAs are gene regulators that work through a posttranscriptional repression mechanism. Dysregulation of microRNA expression could lead to a variety of disorders, in particular, human cancer, and has also been implicated in antihormone therapy resistance. However, little is k...
作者:... Singh M , Sachdeva M , Safe S
来源:[J].Oncogene, 2012, Vol.31 (27), pp.3265-76PubMed
摘要:The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell lung cancer A549 and H460 cells, and knockdown of TR3 by RNA inter...
作者:Sachdeva M , Mullin S ...
来源:[J].Antimicrobial agents and chemotherapy, 2012, Vol.56 (8), pp.4463-5PubMed
摘要:LFF571 is a novel semisynthetic thiopeptide and potent inhibitor of Gram-positive bacteria. We report that the antibacterial activity of LFF571 against Clostridium difficile is due to inhibition of translation. Single-step mutants of C. difficile with reduced susceptibility ...
作者:Sachdeva M , Shao J ...
来源:[J].Antimicrobial agents and chemotherapy, 2011, Vol.55 (11), pp.5277-83PubMed
摘要:Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like GE2270 A, target the essential bacterial protein elongation factor Tu (EF-Tu). Medicinal chemistry optimization of lead molecules led to the identification of preclinical...

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