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作者:... Bruce Miller , John Souness , Stevan Djuric
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 1998, Vol.8 (19), pp.2737-2742Elsevier
摘要:Abstract(#br)A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.
作者:... Richard Labaudiniere , John Souness , Stevan Djuric
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 1998, Vol.8 (4), pp.399-404Elsevier
摘要:Abstract(#br)This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC 50 's for PDE IV inhibition.

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