全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Sébastien Goutal , Matthieu Gerstenmayer ...
来源:[J].Journal of Controlled Release(IF 7.633), 2018
摘要:Abstract(#br)Overcoming the efflux mediated by ATP–binding cassette (ABC) transporters at the blood-brain barrier (BBB) remainsss a challenge for the delivery of small molecule tyrosine kinase inhibitors (TKIs) such as erlotinib to the brain. Inhibition of ABCB1 and ABCG2 at...
作者:Sébastien Goutal , Leopold Eymin ...
来源:[J].Neurobiology of Disease(IF 5.624), 2019, Vol.130
摘要:Abstract(#br)As research progresses in the understanding of the molecular and cellular mechanisms underlying neurodegenerative diseases like Huntington's disease (HD) and expands towards preclinical work for the development of new therapies, highly relevant animal models are incr...
作者:Sébastien Goutal , Benoît Thézé ...
来源:[J].Drug and Alcohol Dependence(IF 3.141), 2017, Vol.170, pp.43-50
摘要:Abstract(#br)Introduction(#br)A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine...
作者:Sébastien Goutal , Sylvain Auvity ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Sébastien Goutal , Solène Marie ...
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10
摘要:Abstract(#br) Background(#br)Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome...
作者:Sébastien Goutal , Bertrand Kuhnast ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2013, Vol.40 (7), pp.887-895
摘要:Abstract(#br)Introduction(#br)[ 18 F]Fallypride, a fluorinated and substituted benzamide with high affinity for D 2 /D 3 receptors, is a useful PET radioligand for the study of striatal/extrastriatal areas. Since [ 18 F]fallypride is extensively metabolized in vivo and since...
作者:Sébastien Goutal , Michel Bottlaender
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (2), pp.227-233
摘要:Abstract(#br)Background(#br)LBT-999 (E)- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane is a dopamine transporter (DAT) ligand. [ 18 F]LBT-999 was first labelled with carbon-11; we will now describe its in vivo behaviour in comparison to that of [ 11 C]LBT-9...
作者:Sébastien Goutal , Christine Coulon ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2012, Vol.39 (3), pp.347-359
摘要:Abstract(#br)Introduction(#br)LBT-999, ( E )- N -(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane, has been developed for PET imaging of the dopamine transporter. [ 18 F]LBT-999 PET studies in baboons showed a lower brain uptake than [ 11 C]LBT-999 and a high bon...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×