全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Briana Franz , Russell S Thomas , John F Wambaugh
来源:[J].PLoS ONE(IF 3.73), 2019, Vol.14 (5)DOAJ
摘要:Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologically based toxicokinetic (PBTK...
作者:Russell S Thomas , Scott S Auerbach
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (5)DOAJ
摘要:Several groups have employed genomic data from subchronic chemical toxicity studies in rodents (90 days) to derive gene-centric predictors of chronic toxicity and carcinogenicity. Genes are annotated to belong to biological processes or molecular pathways that are mechanistically...
作者:Russell S Thomas , Laura S Chubb ...
来源:[J].Cancer Letters(IF 4.258), 1998, Vol.129 (1), pp.39-44Elsevier
摘要:Abstract(#br)1,2,4,5-Tetrachlorobenzene (TeCB) and 1,4-dichlorobenzene (DCB) are important environmental contaminants that have been used extensively for a variety of industrial applications. Limited data are available in the literature regarding the carcinogenicity of TeCB. DCB ...
作者:Russell S Thomas , Donald P McDonnell
来源:[J].The Journal of Pathology(IF 7.585), 2015, Vol.235 (1), pp.101-112Wiley
摘要:Abstract(#br)The aryl hydrocarbon receptor ( AhR ) is a heterodimeric transcriptional regulator with pleiotropic functions in xenobiotic metabolism and detoxification, vascular development and cancer. Herein, we report a previously undescribed role for the AhR signalling pat...

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