全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ruili Huang , Menghang Xia
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (12), pp.3885-3895Springer
摘要:Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken w...
作者:... Zhichao Liu , Ruili Huang , Weida Tong
来源:[J].BMC Bioinformatics(IF 3.024), 2016, Vol.17 (13)Springer
摘要:Abstract(#br) Background(#br)All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molec...
作者:Ruili Huang , Robert L Walker ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (11)DOAJ
摘要:Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The la...
作者:Ruili Huang , Diana A. Stavreva ...
来源:[J].Toxicology(IF 4.017), 2017, Vol.385, pp.48-58Elsevier
摘要:Abstract(#br)The androgen receptor (AR, NR3C4) is a nuclear receptor whose main function is acting as a transcription factor regulating gene expression for male sexual development and maintaining accessory sexual organ function. It is also a necessary component of female fer...
作者:Ruili Huang , Harutoshi Kato ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2017, Vol.106 (7), pp.1752-1759Elsevier
摘要:Abstract(#br)The activation of pregnane X receptor (PXR), a member of the nuclear receptor superfamily, can mediate potential drug-drug interactions by regulating the expression of several drug-mediated enzymes and transporters, resulting in reduced therapeutic efficacy or increa...
作者:Ruili Huang , Mike Mikailov ...
来源:[J].Drug Discovery Today(IF 6.551), 2018Elsevier
摘要:Drug-induced rhabdomyolysis (DIR) is an idiosyncratic and fatal adverse drug reaction (ADR) characterized in severe muscle injuries accompanied by multiple-organ failure. Limited knowledge regarding the pathophysiology of rhabdomyolysis is the main obstacle to developing early bi...
作者:Ruili Huang , Matthew Brecher ...
来源:[J].Antiviral Research(IF 3.925), 2018, Vol.150, pp.217-225Elsevier
摘要:Abstract(#br)Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guil...
作者:Ruili Huang , Wenjun Bao ...
来源:[J].Drug Discovery Today(IF 6.551), 2018, Vol.23 (2), pp.382-394Elsevier
摘要:There are tremendous unmet needs in drug development for rare diseases. Computational drug repositioning is a promising approach and has been successfully applied to the development of treatments for diseases. However, how to utilize this knowledge and effectively conduct and imp...
作者:Ruili Huang , Michael F. Santillo ...
来源:[J].Toxicology in Vitro(IF 2.65), 2019Elsevier
摘要:Abstract(#br)The inhibition of acetylcholinesterase (AChE) has pharmaceutical applications as well as potential neurotoxic effects. The in vivo metabolites of some chemicals including organophosphorus pesticides can become more potent AChE inhibitors compared to their parental co...
作者:... Menghang Xia , Christopher P. Austin , Ruili Huang
来源:[J].The AAPS Journal(IF 4.386), 2012, Vol.14 (3), pp.473-480Springer
摘要:Abstract(#br)The limitations of traditional toxicity testing characterized by high-cost animal models with low-throughput readouts, inconsistent responses, ethical issues, and extrapolability to humans call for alternative strategies for chemical risk assessment. A new strat...

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