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作者:Rosa M. Pascale , Diego F. Calvisi ...
来源:[J].The American Journal of Pathology(IF 4.522), 2019, Vol.189 (5), pp.1077-1090
摘要:Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA doma...
作者:Rosa M. Pascale , Antonio Cossu ...
来源:[J].Journal of Hepatology(IF 9.858), 2017
摘要:Background & Aims(#br)Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxal...
作者:Rosa M. Pascale , Graziella Peitta ...
来源:[J].Medicina(IF 0.55), 2019, Vol.55 (6)
摘要:Several researchers have analyzed the alterations of the methionine cycle associated with liver disease to clarify the pathogenesis of human hepatocellular carcinoma (HCC) and improve the preventive and the therapeutic approaches to this tumor. Different alterations of the m...
作者:Rosa M. Pascale , Christy Joseph ...
来源:[J].DNA Repair(IF 4.274), 2016, Vol.47, pp.12-20
摘要:Abstract(#br)Hepatocellular carcinoma (HCC) is a frequent and deadly disease worldwide. The absence of effective therapies when the tumor is surgically unresectable leads to an extremely poor outcome of HCC patients. Thus, it is mandatory to elucidate the molecular pathogenesis o...
作者:Rosa M. Pascale , Frank Dombrowski ...
来源:[J].Journal of Hepatology(IF 9.858), 2016, Vol.64 (2), pp.333-341
摘要:Background & Aims(#br)Cumulating evidence underlines the crucial role of aberrant lipogenesis in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of fatty acid synthase (FASN), the master regulator of de novo lipogenesis, in the mouse liver.(#br...
作者:Rosa M. Pascale , Maria M. Simile ...
来源:[J].Alcohol(IF 2.255), 2002, Vol.27 (3), pp.193-198
摘要:Abstract(#br)Accumulation of genetic changes characterizes the progression of cells, initiated by carcinogens, to full malignancy. Various epigenetic mechanisms, such as high polyamine synthesis, aberrant DNA methylation, and production of reactive oxygen species, may favor ...
作者:... Maria L. Tomasi , Francesco Feo , Rosa M. Pascale
来源:[J].BBA - Reviews on Cancer(IF 9.033), 2012, Vol.1826 (1), pp.215-237
摘要:Abstract(#br)Hepatocellular carcinoma is a frequent and fatal disease. Recent researches on rodent models and human hepatocarcinogenesis contributed to unravel the molecular mechanisms of hepatocellular carcinoma dedifferentiation and progression, and allowed the discovery o...
作者:... Fiorella Biasi , Francesco Feo , Rosa M. Pascale
来源:[J].Molecular Aspects of Medicine(IF 10.375), 2010, Vol.31 (2), pp.179-193
摘要:Abstract(#br)Hepatocellular carcinoma (HCC) is the fifth most frequent human cancer and a fatal disease. Therapies with pharmacological agents do not improve the prognosis of patients with unresectable HCC. This emphasizes the need to identify new targets for early diagnosis, che...
作者:Maddalena Frau , Francesco Feo , Rosa M. Pascale
来源:[J].Journal of Hepatology(IF 9.858), 2013, Vol.59 (4), pp.830-841
摘要:Summary(#br)Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A , encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Being inhi...
作者:... Dae–Sik Lim , Francesco Feo , Rosa M. Pascale
来源:[J].Gastroenterology(IF 12.821), 2009, Vol.137 (5), pp.1816-1826.e10
摘要:Background & Aims(#br)The cell cycle regulators P21 WAF1 , P27 KIP1 , P57 KIP2 , P130, RASSF1A, and FOXO1 are down-regulated during hepatocellular carcinoma (HCC) pathogenesis. We investigated the role of the ubiquitin ligase subunits CKS1 and SKP2, which regulate proteasome degr...

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