全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Roman Hudec , Thomas R. Caulfield ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. T...
作者:Roman Hudec , Wang-Xia Wang ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2016, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy, a selective autophagic clearance ...
作者:Roman Hudec , Ján Sedlák ...
来源:[J].Toxicology in Vitro(IF 2.65), 2016, Vol.33, pp.35-44Elsevier
摘要:Abstract(#br)7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2 h ) is a new synthetically prepared quinolone derivative, which in our primary study showed cytotoxic effects towards tumor cells. The aim of the present study was to examine th...
作者:Roman Hudec , Kozo Hamada , Katsuhiko Mikoshiba
来源:[J].Analytical Biochemistry(IF 2.582), 2013, Vol.433 (2), pp.95-101Elsevier
摘要:Abstract(#br)The methylation of DNA, RNA, and proteins plays crucial roles in numerous biological processes, including epigenetic control, virus replication, and cell differentiation. In mammals, the rate-limiting step of the S -adenosylmethionine-dependent methylation process is...
作者:Roman Hudec , Boris Lakatoš ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2004, Vol.325 (4), pp.1172-1179Elsevier
摘要:Abstract(#br)The 45 Ca 2+ influx into right-side-out resealed ghosts (RG) prepared from human red blood cells (RBC) was measured. The 45 Ca 2+ equilibration occurred with t 1/2 = 2.5 min and the steady-state was reached after 17 min with the level of 22 ± 2 μmol/L packed ce...
作者:Roman Hudec , Boris Lakatoš ...
来源:[J].BBA - Biomembranes(IF 3.389), 2004, Vol.1661 (2), pp.204-211Elsevier
摘要:Abstract(#br)The basal 45 Ca 2+ influx in human red blood cells (RBC) into intact RBC was measured. 45 Ca 2+ was equilibrated with cells with t 1/2 =15–20 s and the influx reached the steady state value in about 90–100 s and the steady state level was 1.5±0.2 μmol/l pac...

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