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作者:Rohan Lourie , Admire Matsika ...
来源:[J].Oncogene(IF 7.357), 2020, Vol.39 (2), pp.219-233
摘要:Abstract(#br)Elevated CUB-domain containing protein 1 (CDCP1) is predictive of colorectal cancer (CRC) recurrence and poor patient survival. While CDCP1 expression identifies stem cell populations that mediate lung metastasis, mechanisms underlying the role of this cell surf...
作者:Rohan Lourie , Geraint B Rogers ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)
摘要:Non-cystic fibrosis (CF) bronchiectasis is characterised by chronic airway infection and neutrophilic inflammation, which we hypothesised would be associated with Th17 pathway activation.Th17 pathway cytokines were quantified in bronchoalveolar lavage fluid (BALF), and gene ...
作者:Rohan Lourie , Veronika Schreiber ...
来源:[J].Oncogene(IF 7.357), 2019, Vol.38 (48), pp.7294-7310
摘要:Abstract(#br)Many adenocarcinomas, including colorectal cancer (CRC), overexpress the MUC13 cell surface mucin, but the functional significance and mechanisms are unknown. Here, we report the roles of MUC13 in colonic tumorigenesis and tumor progression. High-MUC13 expressio...
作者:Rohan Lourie , Hui Tong ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.265-368
摘要:Abstract(#br)Prolonged high fat diets (HFD) induce low-grade chronic intestinal inflammation in mice, and diets high in saturated fat are a risk factor for the development of human inflammatory bowel diseases. We hypothesized that HFD-induced endoplasmic reticulum (ER)/oxidative ...

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