全部文献期刊会议图书|学者科研项目
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作者:Rodrigo A. Cunha , Carlos M. Palmeira
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.179-190
摘要:Although adenosine A1 receptors (A1R) have been associated to ischemic preconditioning (IPC), direct evidence for their ability to preserve mitochondrial function upon hepatic preconditioning is still missing and could represent a novel strategy to boost the quali...
作者:João P. Lopes , Anna Pliássova , Rodrigo A. Cunha
来源:[J].Biochemical Pharmacology(IF 4.576), 2019, Vol.166, pp.313-321
摘要:Abstract(#br)Caffeine is the most consumed psychoactive drug worldwide and its intake in moderate amounts prevents neurodegenerative disorders. However, the molecular targets of caffeine to modulate activity in brain circuits are ill-defined. By electrophysiologically record...
作者:... Víctor Fernández-Dueñas , Rodrigo A. Cunha , Francisco Ciruela
来源:[J].Neuroscience Letters(IF 2.026), 2017, Vol.638, pp.162-166
摘要:Abstract(#br)GPR37 is an orphan G protein-coupled receptor highly expressed in the brain. The precise function of GPR37 is still unknown, but a number of evidences indicate it modulates the dopaminergic system. Here, we aimed to determine the role of GPR37 on the control of ...
作者:Rodrigo A. Cunha , João Pedro Lopes
来源:[J].Neurobiology of Disease(IF 5.624), 2018, Vol.117, pp.72-81
摘要:Abstract(#br)Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A 2A receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over-activation of adenosine A 2A receptors (A 2A R) causes memory deficits and the bloc...
作者:Ricardo J. Rodrigues , Joana M. Marques , Rodrigo A. Cunha
来源:[J].Seminars in Cell and Developmental Biology(IF 6.202), 2019, Vol.95, pp.34-41
摘要:Abstract(#br)ATP and adenosine are released from cells as a function of their metabolic activity, being important cell-to-cell communication signals. Both purines are also released from neurons in an activity-dependent manner, with several established roles to fine tune brain fun...
作者:... Daniel Rial , Paula Agostinho , Rodrigo A. Cunha
来源:[J].Neurobiology of Disease(IF 5.624), 2019, Vol.132
摘要:Abstract(#br)Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42 )-based model of early AD, we now unraveled that this involves an increased synaptic release of ATP coupled to an inc...
作者:... Enéas A. Fontes-Júnior , Rodrigo A. Cunha , Cristiane S.F. Maia
来源:[J].Behavioural Brain Research(IF 3.327), 2018, Vol.350, pp.99-108
摘要:Abstract(#br)Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. W...
作者:... Ângelo R. Tomé , Rodrigo A. Cunha , Carlos Robalo Cordeiro
来源:[J].Pulmonary Pharmacology & Therapeutics(IF 2.543), 2017, Vol.45, pp.90-94
摘要:Abstract(#br)Chronic inflammatory lung diseases remain a health concern and new anti-inflammatory treatments are needed. Targeting adenosine A 2A receptors (A 2A R) affords robust anti-inflammatory effects in animal models, but the translation of this promising strategy to h...
作者:Rodrigo A. Cunha , Rodrigo A. Cunha ...
来源:[J].Frontiers in Pharmacology, 2018, Vol.9
摘要:Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent behavior such as working memory,...
作者:Rodrigo A. Cunha , Víctor Fernández-Dueñas
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (1), pp.1-13
摘要:Abstract G protein-coupled receptor 37 (GPR37 is an orphan receptor associated to Parkinson’s disease (PD neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A2A receptor (A2AR cell surface expression and function in vivo. In addition, we showed that GPR37...

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