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作者:Robert J Unwin , Jill T Norman ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (9)
摘要:BACKGROUND: Vitamin A is necessary for kidney development and has also been linked to regulation of solute and water homeostasis and to protection against kidney stone disease, infection, inflammation, and scarring. Most functions of vitamin A are mediated by its main active form...
作者:Robert J Unwin , Giovambattista Capasso
来源:[J].Current Opinion in Pharmacology(IF 5.443), 2006, Vol.6 (2), pp.208-213
摘要:The wider recognition of inherited Bartter's and Bartter's-like syndromes, especially Gitelman's, has come largely as a result of the advances in, and application of, molecular genetics. By exploiting pre-existing renal cell models of ion transport, specifically for sodium a...
作者:... Geoffrey Burnstock , Robert J Unwin , Philip M Dunn
来源:[J].Biochemical Pharmacology(IF 4.576), 2003, Vol.66 (3), pp.415-424
摘要:Abstract(#br)We have generated and characterised a clone of chicken DT40 lymphocytes stably transfected with the rat P2X 7 receptor (rP2X 7 ). Successful transfection was confirmed by Western blotting. Under voltage clamp, P2X 7 -expressing cells responded to ATP and dibenzo...
作者:... Sebastian Bachmann , Robert J Unwin , David H Ellison
来源:[J].Nature Medicine(IF 22.864), 2011, Vol.17 (10), pp.1304-1309
摘要:Calcineurin inhibitors, such as tacrolimus, are widely used immunosuppressive agents, but they can cause hypertension. In studies of tacrolimus-treated mice, the authors show that hypertension is due to activation of the sodium chloride transporter NCC in the kidney, causing sodi...
作者:Robert J Unwin , Steven D Soroka ...
来源:[J].Nature Genetics(IF 35.209), 2012, Vol.44 (suppl. 1), pp.456-460
摘要:Xavier Jeunemaitre, Jean-Jacques Schott and colleagues report mutations of KLHL3 in familial hyperkalemic hypertension. KLHL3 encodes a BTB-BACK-kelch family actin-binding protein and regulates cell surface localization of the NaNa+-Cl cotransporter, a...
作者:Robert J Unwin , Steven D Soroka ...
来源:[J].Nature Genetics(IF 35.209), 2012, Vol.44 (5), pp.609-609
摘要:Nat. Genet. 44, 456–460 (2012); published online 11 March 2012; corrected after print 22 March 2012 In the version of this article initially published, two references were omitted, resulting in several statements being incorrectly attributed in the Online Methods. In the 'Pe...
作者:Christopher Laing , Robert J Unwin
来源:[J].Current Opinion in Nephrology and Hypertension(IF 3.964), 2000, Vol.9 (5), pp.489-495
摘要:Long-acting calcium antagonists have been shown to be safe and effective in lowering blood pressure, both as first-line agents and in combination with other classes of antihypertensive drug. They have also been shown to reduce the incidence of cerebrovascular and cardiovascu...
作者:Matthew A Bailey , Kate A Hillman , Robert J Unwin
来源:[J].Journal of the Autonomic Nervous System, 2000, Vol.81 (1), pp.264-270
摘要:Abstract(#br)Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of ...

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