全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Robert Hilbrands , Kathelijn Keymolen ...
来源:[J].BMC Medical Genetics(IF 2.536), 2017, Vol.18 (1)Springer
摘要:Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development.
作者:Robert Hilbrands , Ursule Velde ...
来源:[J].Diabetologia(IF 6.487), 2018, Vol.61 (7), pp.1623-1632Springer
摘要:Abstract(#br) Aims/hypothesis(#br) HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the ...
作者:Robert Hilbrands , Zhidong Ling ...
来源:[J].Transplantation(IF 3.781), 2017, Vol.101 (9), pp.2218-2227Wolters Kluwer
摘要:BACKGROUND: Induction therapy with a T cell–depleting agent followed by mycophenolate mofetil and tacrolimus is presently the most frequently used immune suppression (IS) regimen in islet transplantation. This study assesses its safety and tolerability in nonuremic type 1 di...
作者:Robert Hilbrands , Kathelijn Keymolen ...
来源:[J].2017, Vol.18 (1), pp.57BMC
摘要:Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development. We report a case of a Caucasian female with complete pancreatic agenesis o...
作者:Robert Hilbrands , Bart Keymeulen ...
来源:[J].Journal of Autoimmunity(IF 8.145), 2011, Vol.37 (3), pp.151-159Elsevier
摘要:Abstract(#br)Autoreactive cytotoxic CD8 T-cells (CTLs) play a key pathogenic role in the destruction of insulin-producing beta-cells resulting in type 1 diabetes. However, knowledge regarding their targets is limited, restricting the ability to monitor the course of the dise...
作者:Robert Hilbrands , DaHae Lee ...
来源:[J].Diabetes Care(IF 7.735), 2016, Vol.39 (6)ProQuest
摘要:We investigated whether changes in islet autoantibody profile and presence of HLA risk markers, reported to predict rapid β-cell loss in pre-type 1 diabetes, associate with poor functional outcome in islet allograft recipients. Forty-one patients received ≥2.3 million β-cell...
作者:Robert Hilbrands , Gabriëlle G. M. Pinkse ...
来源:[J].PLOS ONE(IF 3.73), 2008, Vol.3 (6)PLOS
摘要:Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin–independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograf...

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