全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Candace Summerford , Jeffrey S. Bartlett , Richard Jude Samulski
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.9 -32Brill Press
摘要:A wide stream of in vivo studies have now confirmed the prediction that rAAV vectors have the primary requirements for effective gene transfer. AAV vectors can efficiently transduce both dividing and non-dividing cells, they are able to mediate long-term gene expression, and are ...
作者:... Douglas McCarty , Richard Jude Samulski , Ronald G. Thurman
来源:[J].Hepatology(IF 12.003), 2000, Vol.32 (5), pp.1050-1059Elsevier
摘要:Abstract(#br)Recombinant adeno-associated virus (rAAV) transduction is limited in vivo , yet can be enhanced by hydroxyurea, ultraviolet-irradiation, or adenovirus coinfection, possibly via mechanisms involving stress in the host cell. Because chronic ethanol induces oxidati...
作者:Fabienne Rolling , Richard Jude Samulski
来源:[J].Molecular Biotechnology(IF 2.262), 1995, Vol.3 (1), pp.9-15Springer
摘要:Abstract(#br)Investigation of the adeno-associated virus (AAV) life cycle has enabled the establishment of methodology and identification of critical cis-acting sequences required for recombinant AAV production. Vectors derived from the defective human parvovirus (AAV) have been ...
作者:Joseph Rabinowitz , Ying Kai Chan , Richard Jude Samulski
来源:[J].Viruses(IF 2.509), 2019, Vol.11 (2)MDPI
摘要:Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including tissue targeting, delivery across the blood–brain barrier (BBB), and host immune responses. These issues remain pertinent till today. Since then, several advances have been made in eluci...

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