全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Reuben Thomas , Biljana Djukic ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways. This process (excitotoxicity) has been i...
作者:Reuben Thomas , Susan Newbigging ...
来源:[J].Journal of Cardiovascular Magnetic Resonance, 2017, Vol.19 (1)Springer
摘要:Myocardial hemorrhage is a frequent complication following reperfusion in acute myocardial infarction and is predictive of adverse outcomes. However, it remains unsettled whether hemorrhage is simply a marker of a severe initial ischemic insult or directly contributes to downstre...
作者:Reuben Thomas , Russell S Thomas ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (5)DOAJ
摘要:Several groups have employed genomic data from subchronic chemical toxicity studies in rodents (90 days) to derive gene-centric predictors of chronic toxicity and carcinogenicity. Genes are annotated to belong to biological processes or molecular pathways that are mechanistically...
作者:Reuben Thomas , Alan E Hubbard ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (6)DOAJ
摘要:Characterization of toxicogenomic signatures of carcinogen exposure holds significant promise for mechanistic and predictive toxicology. In vitro transcriptomic studies allow the comparison of the response to chemicals with diverse mode of actions under controlled experimental co...
作者:Reuben Thomas , Alex Loguinov ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (8)DOAJ
摘要:Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene to...
作者:Reuben Thomas , Martyn T Smith ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (1)DOAJ
摘要:Recent genome-wide association studies (GWAS) have identified several gene variants associated with sporadic chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Many of these CLL/SLL susceptibility loci are located in non-coding or intergenic regions, posing a...

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