全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Renato J. Scialis , Sarah Lazzaro ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.787-796Springer
摘要:Transporter-mediated hepatic uptake is proven to be the rate-determining step in the systemic clearance of several drugs. Therefore, accurate measurement of active and passive uptake clearances in vitro is critical to facilitate pharmacokinetics and drug-drug interaction pre...
作者:Renato J. Scialis , Jian Lin ...
来源:[J].The AAPS Journal(IF 4.386), 2014, Vol.16 (4), pp.736-748Springer
摘要:Abstract(#br)The purpose of this study is to characterize the involvement of hepato-biliary transport and cytochrome-P450 (CYP)-mediated metabolism in the disposition of glyburide and predict its pharmacokinetic variability due to drug interactions and genetic variations. Co...
作者:Renato J. Scialis , Haojing Rong
来源:[J].Biopharmaceutics & Drug Disposition(IF 2.09), 2012, Vol.33 (2), pp.72-84Wiley
摘要:ABSTRACT(#br)Positive allosteric modulators (‘potentiators’) of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) have been shown to display a mechanism‐based exposure–response continuum in preclinical species with procognitive ele...
作者:Renato J. Scialis , Charles J. Rotter ...
来源:[J].Xenobiotica(IF 1.984), 2013, Vol.43 (11), pp.963-972Informa Healthcare
摘要:Abstract 1. 5-( N -(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), an agonist of the peroxisome proliferator-activated receptor alpha, has been evaluated in the clinic to treat dyslipidemia and type 2 diabetes mellitus. Herein,...
作者:Renato J. Scialis , Iván L. Csanaky ...
来源:[J].Drug Metabolism and Disposition, 2015, Vol.43 (7), pp.944-950Duke University Press
摘要:Diclofenac (DCF) is a nonsteroidal anti-inflammatory drug commonly prescribed to reduce pain in acute and chronic inflammatory diseases. One of the main DCF metabolites is a reactive diclofenac acyl glucuronide (DCF-AG) that covalently binds to biologic targets and may contribute...

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