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作者:... Rui Werner Maçedo Krause , René Wintjens , Guy Anathole Blaise Azebaze
来源:[J].Journal of Ethnopharmacology(IF 2.755), 2020
摘要:Abstract(#br)Ethnopharmacological relevance(#br)The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, cough, various urino-genital, meningitis, abdominal pain, w...
作者:... Nicolas Willand , Alain R. Baulard , René Wintjens
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.487 (2), pp.403-408
摘要:Abstract(#br)Inhibition of transcriptional regulators of bacterial pathogens with the aim of reprogramming their metabolism to modify their antibiotic susceptibility constitutes a promising therapeutic strategy. One example is the bio-activation of the anti-tubercular pro-dr...
作者:René Wintjens , Nicolas Willand
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.167
摘要:Abstract(#br)Tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis , represents one of the most challenging threat to public health worldwide, and with the increasing resistance to approved TB drugs, it is needed to develop new strategies to address this issue. Ethi...
作者:... Pascale Van Vooren , René Wintjens , Anna Maria Marini
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)
摘要:Proteins of the conserved Mep-Amt-Rh family, including mammalian Rhesus factors, mediate transmembrane ammonium transport. Ammonium is an important nitrogen source for the biosynthesis of amino acids but is also a metabolic waste product. Its disposal in urine plays a critical ro...
作者:... Jean-Yves Springael , René Wintjens , Anna Maria Marini
来源:[J].PLoS Genetics(IF 8.694), 2015, Vol.11 (7)
摘要:Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocytosis of amino-acid transporters...
作者:René Wintjens , Jacky Liévin ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2000, Vol.302 (2), pp.393-408
摘要:Abstract(#br)Cation-π interactions between an aromatic ring and a positive charge located above it have proven to be important in protein structures and biomolecule associations. Here, the role of these interactions at the interface of protein-DNA complexes is investigated, ...
作者:René Wintjens , Marianne Rooman
来源:[J].Journal of Molecular Biology(IF 3.905), 1996, Vol.262 (2), pp.294-313
摘要:Abstract(#br)This paper constitutes an attempt to rationalize the structural similarities and differences that are observed among the HTH DNA-binding domains, and the various modes of protein – DNA interactions. It consists of classifying all the domains of known structure i...
作者:René Wintjens , Hassan Belrhali ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2005, Vol.357 (2), pp.457-470
摘要:Glutaminyl cyclases (QCs) (EC 2.3.2.5) catalyze the intramolecular cyclization of protein N-terminal glutamine residues into pyroglutamic acid with the concomitant liberation of ammonia. QCs may be classified in two groups containing, respectively, the mammalian enzymes, and...
作者:René Wintjens , Tran Melody Vu Ngoc Viet ...
来源:[J].Plant Science(IF 2.922), 2011, Vol.181 (4), pp.347-354
摘要:Abstract(#br)Human perception of sweetness, behind the felt pleasure, is thought to play a role as an indicator of energy density of foods. For humans, only a small number of plant proteins taste sweet. As non-caloric sweeteners, these plant proteins have attracted attention as c...
作者:René Wintjens , Helène Jouin ...
来源:[J].Molecular & Biochemical Parasitology(IF 2.734), 2004, Vol.137 (1), pp.121-132
摘要:Abstract(#br)The intraerythrocytic stages of Plasmodium falciparum are exposed to oxidative stress and require functional anti-oxidant systems to survive. In addition to the parasite’s known iron-dependent superoxide dismutase PfSOD1, a second SOD gene ( PfSOD2 ) interrupted...

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