全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:René Grée , Raghida Abou Merhi ...
来源:[J].Chemistry Central Journal(IF 1.312), 2012, Vol.6 (1), pp.1-11Springer
摘要:Abstract(#br) Background(#br)Thromboxane A 2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing t...
作者:Danielle Grée , Olivier Tasseau ...
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2013, Vol.9 (1), pp.1943-1948DOAJ
摘要:Starting from easily accessible gem -difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem -difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem -difluoroalkyl side chain by cy...
作者:René Grée , Ali Hachem ...
来源:[J].Genes & Genomics(IF 0.497), 2019, Vol.41 (12), pp.1431-1443Springer
摘要:Abstract(#br) Background(#br)Breast cancer, the most commonly diagnosed malignancy in women, accounts for the highest cancer-related deaths worldwide. Triple negative breast cancer (TNBC), lacking the expression of estrogen, progesterone and HER2 receptors, has an aggressive...
作者:... Dwaipayan Bhattacharya , Pranav C. Joshi , René Grée
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018, Vol.28 (4), pp.673-676Elsevier
摘要:Abstract(#br)Longanlactone analogues were synthesized using a route featuring Friedel-Crafts acylation, Sonogashira coupling and 1,3-dipolar cycloaddition reactions. Structure–activity relationships were investigated for neurotrophic activity. Compound 6 was found to have th...
作者:... Thierry Roisnel , René Grée , Ali Hachem
来源:[J].Tetrahedron Letters(IF 2.397), 2018Elsevier
摘要:Abstract(#br)Starting from easily accessible gem -difluoropropargylic derivatives a cascade nucleophilic substitution by N 3 - , followed by an intramolecular 1,3 dipolar cycloaddition, afforded in fair to good yields new 1,2,3-triazoles fused to pyrrolidines or piperidines. Thes...
作者:Martin Breugst , René Grée , K. N. Houk
来源:[J].J. Org. Chem., 2013, Vol.78 (19), pp.9892鈥?897ACS
摘要:† Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States ...
作者:... Paul Mosset , René Grée , Majed Kammoun
来源:[J].Journal of Saudi Chemical Society(IF 1.288), 2019, Vol.23 (8), pp.1049-1059Elsevier
摘要:Abstract(#br)Oleuropein is the major phenolic compound extracted from olive leaves and it is also present in olive fruits and virgin olive oil. It has already demonstrated a wide range of pharmacological activities, but new derivatives have to be designed in order to obtain ...

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