全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:René Grée , Raghida Abou Merhi ...
来源:[J].Chemistry Central Journal(IF 1.312), 2012, Vol.6 (1), pp.1-11Springer
摘要:Abstract(#br) Background(#br)Thromboxane A 2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing t...
作者:Danielle Grée , Olivier Tasseau ...
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2013, Vol.9 (1), pp.1943-1948DOAJ
摘要:Starting from easily accessible gem -difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem -difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem -difluoroalkyl side chain by cy...
作者:... Dwaipayan Bhattacharya , Pranav C. Joshi , René Grée
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018, Vol.28 (4), pp.673-676Elsevier
摘要:Abstract(#br)Longanlactone analogues were synthesized using a route featuring Friedel-Crafts acylation, Sonogashira coupling and 1,3-dipolar cycloaddition reactions. Structure–activity relationships were investigated for neurotrophic activity. Compound 6 was found to have th...
作者:... Thierry Roisnel , René Grée , Ali Hachem
来源:[J].Tetrahedron Letters(IF 2.397), 2018Elsevier
摘要:Abstract(#br)Starting from easily accessible gem -difluoropropargylic derivatives a cascade nucleophilic substitution by N 3 - , followed by an intramolecular 1,3 dipolar cycloaddition, afforded in fair to good yields new 1,2,3-triazoles fused to pyrrolidines or piperidines. Thes...
作者:Martin Breugst , René Grée , K. N. Houk
来源:[J].J. Org. Chem., 2013, Vol.78 (19), pp.9892鈥?897ACS
摘要:† Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States ...
作者:... Philippe Juin , Olivier Tasseau , René Grée
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2015, Vol.23 (8), pp.1747-1757Elsevier
摘要:Abstract(#br)Inhibition of Bcl-2 family protein–protein interactions (PPI) is a very promising direction in cancer chemotherapy. Hence over the last decade, many medicinal chemistry studies endeavoured to discover drug candidates, and a wealth of chemical scaffolds with stri...
作者:... Philippe Juin , Nicolas Levoin , René Grée
来源:[J].Tetrahedron(IF 2.803), 2014, Vol.70 (2), pp.301-311Elsevier
摘要:Abstract(#br)We describe here the synthesis of a series of new molecules containing phenol and heteroaromatic moieties, compounds, which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in BRET assays. Among them, a triazole derivative 13 , exhibit a very ...
作者:Danielle Grée , Corinne Aubert
来源:[J].Journal of Fluorine Chemistry(IF 1.939), 2014, Vol.162, pp.32-37Elsevier
摘要:Abstract(#br)The preparation of the new title compounds has been performed using a short and efficient strategy. Starting from appropriately substituted propargylic fluorides, intramolecular enyne metathesis reactions afford in excellent yields 1,3 dienes with the fluorinate...
作者:... Vincent Dorcet , Ali Hachem , René Grée
来源:[J].Tetrahedron Letters(IF 2.397), 2016, Vol.57 (18), pp.1990-1993Elsevier
摘要:Abstract(#br)The Kinugasa reaction applied to alkynes bearing a nucleofuge in propargylic position affords directly, and in fair yields, α-methylene- or α-alkylidene-β-lactams.

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×