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作者:... Ithaar Derweesh , Toni K. Choueiri , Rana R. McKay
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2020
摘要:Abstract(#br)Background(#br)A growing body of evidence suggests that age and gender play a role in cancer outcomes. The objective of this study was to investigate the effect of age and gender on survival of patients with metastatic renal cell carcinoma (RCC).(#br)Methods(#br)We c...
作者:Rana R. McKay , Peter Vu ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2019, Vol.17 (6), pp.443-450.e1Elsevier
摘要:Abstract(#br)Background(#br)The relationship between weight change during treatment and survival remains poorly characterized in patients with metastatic renal cell carcinoma (mRCC).(#br)Patients and Methods(#br)In this retrospective analysis we included 3311 patients with m...
作者:Rana R. McKay , Ulka Vaishampayan ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2019Elsevier
摘要:Abstract(#br)Background(#br)The present retrospective, longitudinal cohort study assessed the association between the first-line sunitinib treatment duration and clinical outcomes with second-line immuno-oncology (IO) therapy among patients with metastatic renal cell carcino...
作者:Rana R. McKay , Xun Lin ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2018, Vol.16 (1), pp.13-20.e3Elsevier
摘要:Abstract(#br)Background(#br)Poor-risk patients with metastatic renal-cell carcinoma remain poorly characterized in prospective clinical trials. Therefore, we sought to provide a comprehensive analysis of this patient population, defined by 3 widely used prognostic models, treated...
作者:Rana R. McKay , Alicia K. Morgans ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2019, Vol.17 (4), pp.275-282.e1Elsevier
摘要:Abstract(#br)Background(#br)Germline genetic testing increasingly identifies advanced prostate cancer (PCa) patients who are candidates for precision therapies. The Prostate Cancer Clinical Trials Consortium (PCCTC) established the Germline Genetics Working Group to provide guida...
作者:... Katherine M. Krajewski , Toni K. Choueiri , Rana R. McKay
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2018, Vol.16 (2), pp.e327-e333Elsevier
摘要:Abstract(#br)Background(#br)Cardiac metastases from renal cell carcinoma (RCC) are uncommon and there are limited data regarding the presentation and outcomes of this population. The objective of this study was to evaluate the characteristics and outcomes of patients with RCC wit...
作者:Rana R. Mckay , Sabrina Noyes ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2019, Vol.17 (3), pp.e505-e512Elsevier
摘要:Abstract(#br)Background(#br)We analyzed outcomes of neoadjuvant sunitinib in patients with renal-cell carcinoma (RCC) and inferior vena caval (IVC) tumor and compared outcomes to patients who did not undergo neoadjuvant therapy before surgery.(#br)Patients and Methods(#br)We perf...
作者:Rana R. McKay , Daniel J. George ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2018Elsevier
摘要:Abstract(#br)Introduction(#br)Genomic events leading to activation of mechanistic target of rapamycin (mTOR) are common in renal cell carcinoma (RCC). Everolimus is an allosteric mTOR inhibitor with efficacy in metastatic RCC. We characterized the genomic profile of RCC tumo...
作者:Rana R. McKay , Xun Lin ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2017, Vol.15 (6), pp.652-660.e1Elsevier
摘要:Abstract(#br)Background(#br)Clinical data from patients with non–clear cell renal cell carcinoma (nccRCC) receiving targeted therapy are limited, and many clinical trials have excluded these patients from study entry. We sought to investigate the outcomes of patients with nc...
作者:Rana R. McKay , Xun Lin ...
来源:[J].Clinical Genitourinary Cancer(IF 1.429), 2017, Vol.15 (6), pp.724-732Elsevier
摘要:Abstract(#br)Introduction(#br)Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion and can affect the optimal absorption of concomitant oral medications, such as vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKIs). The purpose...

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