全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ralf Kircheis , Ernst Wagner
来源:[J].Gene Therapy and Regulation, 2000, Vol.1 (1), pp.95 -114Brill Press
摘要:A major aim of in vivo gene transfer strategies is the efficient and specific delivery of therapeutic genes into the desired target tissues. Non-viral vectors, based on naked plasmid DNA or DNA complexes with cationic lipids or polycationic polymers, are attractive gene delivery ...
作者:Ralf Kircheis , Lionel Wightman , Ernst Wagner
来源:[J].Advanced Drug Delivery Reviews(IF 12.888), 2001, Vol.53 (3), pp.341-358Elsevier
摘要:Abstract(#br)The polycation polyethylenimine (PEI) has recently been widely employed for the design of DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact particles, uptake into the cells, release from the endosomal compartment into the cytopl...
作者:Ralf Kircheis , Petra Vondru ...
来源:[J].Vaccine(IF 3.492), 2005, Vol.24 (13), pp.2349-2357Elsevier
摘要:Abstract(#br)Tumor-associated antigens resulting from aberrant glycosylation, such as the SialylTn carbohydrate antigen, are over-expressed on cancer cells and provide potential targets for cancer vaccination. However, as T-cell-independent antigens carbohydrates are poorly ...
作者:Ralf Kircheis , Thomas Blessing ...
来源:[J].Journal of Controlled Release(IF 7.633), 2001, Vol.72 (1), pp.165-170Elsevier
摘要:Abstract(#br)Incorporation of the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) into DNA/polyethylenimine (PEI) complexes was found to enhance gene transfer into tumor cell lines in a receptor-dependent manner. In systemic applications, the surface ch...
作者:Ralf Kircheis , Markus Wolschek
来源:[J].Journal of Controlled Release(IF 7.633), 2003, Vol.91 (1), pp.173-181Elsevier
摘要:Abstract(#br)Surface-shielded DNA delivery systems have been synthesized with virus-like characteristics that target gene expression into distant tumor tissues. Polyethylenimine (PEI)/DNA complexes (‘polyplexes’) conjugated with the cell-binding ligand transferrin (Tf) or ep...
作者:... Ulrich Schubert , Ralf Kircheis , Oliver Planz
来源:[J].Antiviral Research(IF 3.925), 2011, Vol.91 (3), pp.304-313Elsevier
摘要:Abstract(#br)The appearance of highly pathogenic avian influenza A viruses of the H5N1 subtype being able to infect humans and the 2009 H1N1 pandemic reveals the urgent need for new and efficient countermeasures against these viruses. The long-term efficacy of current antivi...
作者:Ralf Kircheis , Ernst Wagner
来源:[J].Cancer Letters(IF 4.258), 2000, Vol.161 (2), pp.241-250Elsevier
摘要:Abstract(#br)We explored the potential of the xenogenization concept as an adjuvant procedure in anti-tumor immunity. To mediate effective loading we used polyarginine (pArg) molecules of various degrees of polymerization, cationic liposomes, or chimeric molecules of transfe...
作者:Ralf Kircheis , Frank J. Koppenhagen ...
来源:[J].International Journal of Pharmaceutics(IF 3.458), 1999, Vol.183 (1), pp.33-36Elsevier
摘要:Abstract(#br)Subcutaneous vaccination of C57bl/6 mice with irradiated B16 melanoma cells supplemented with liposomal interleukin-2 (IL2) or murine interferon-gamma (mIFNγ), resulted in systemic protection in 50% of the animals, against a subsequent tumor cell challenge in a ...
作者:Ernst Wagner , Ralf Kircheis , Greg F. Walker
来源:[J].Biomedicine & Pharmacotherapy(IF 2.068), 2004, Vol.58 (3), pp.152-161Elsevier
摘要:Abstract(#br)Unique properties of tumors, such as abnormalities in the cell cycle and apoptosis, migration and metastasis, neoangiogenesis or unique antigen profiles are targets for therapeutic anti-cancer strategies. Beyond the selection of such strategies, additional specificit...
作者:... Markus Fido , Ralf Kircheis , Andreas Nechansky
来源:[J].Journal of Chromatography B(IF 2.487), 2007, Vol.852 (1), pp.250-256Elsevier
摘要:Abstract(#br)During the analytical characterization of the humanized Lewis-Y specific monoclonal antibody IGN311 (IgG1/κ) used for passive anti-cancer therapy in humans, isoelectric focusing (IEF) experiments revealed that IGN311 batches produced in serum-containing and seru...

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