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作者:Rafael Luis Kessler , Daniela Parada Pavoni ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Trypanosomatids are a group of protozoan parasites that includes the etiologic agents of important human illnesses as Chagas disease, sleeping sickness and leishmaniasis. These parasites have a significant distinction from other eukaryotes concerning mRNA structure, since al...
作者:Rafael Luis Kessler , Iriane Eger
来源:[J].BMC Cell Biology(IF 2.808), 2018, Vol.19 (1), pp.1-16DOAJ
摘要:Abstract Background The palmitate analogue 2-bromopalmitate (2-BP) is a non-selective membrane tethered cysteine alkylator of many membrane-associated enzymes that in the last years emerged as a general inhibitor of protein S-palmitoylation. Palmitoylation is a post-translat...
作者:Rafael Luis Kessler , Maurilio José Soares ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (1)DOAJ
摘要:The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols. The sterol pathway is thus a potential drug target for the treatment of Chagas dis...
作者:Rafael Luis Kessler , Alexandre Haruo Inoue ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (6)DOAJ
摘要:In eukaryotic cells, different RNA species are exported from the nucleus via specialized pathways. The mRNA export machinery is highly integrated with mRNA processing, and includes a different set of nuclear transport adaptors as well as other mRNA binding proteins, RNA helicases...
作者:Rafael Luis Kessler , Iriane Eger
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (6)DOAJ
摘要:Epimastigote forms of Trypanosoma cruzi (the etiologic agent of Chagas disease) internalize and store extracellular macromolecules in lysosome-related organelles (LROs) called reservosomes, which are positive for the cysteine protease cruzipain. Despite the importance of end...
作者:Rafael Luis Kessler , Víctor Tulio Contreras ...
来源:[J].Molecular Microbiology(IF 4.961), 2017, Vol.104 (5), pp.712-736Wiley
摘要:Summary(#br)Trypanosoma cruzi , the etiologic agent of Chagas disease, has a complex life cycle in which four distinct developmental forms alternate between the insect vector and the mammalian host. It is assumed that replicating epimastigotes present in the insect gut are n...
作者:Rafael Luis Kessler , Sharon Toledo Martins ...
来源:[J].RNA Biology(IF 4.841), 2014, Vol.11 (7), pp.921-933Taylor & Francis
摘要:Trypanosome gene expression is regulated almost exclusively at the posttranscriptional level, through mRNA stability, storage and degradation. Here, we characterize the ribonucleoprotein complex (mRNPs) corresponding to the zinc finger protein TcZC3H39 from T. cruzi comparing cel...

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