全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:R. Pannell , S. Li , V. Gurewich
来源:[J].Journal of Thrombosis and Thrombolysis(IF 1.985), 2017, Vol.44 (2), pp.210-215Springer
摘要:Thrombolysis with tissue plasminogen activator (tPA) has been a disappointment and has now been replaced by an endovascular procedure whenever possible. Nevertheless, thrombolysis remains the only means by which circulation in a thrombosed artery can be restored rapidly. In contr...
作者:R. Pannell , H. Borghi ...
来源:[J].Archives of Cardiovascular Diseases(IF 1.662), 2009, Vol.102, pp.S52-S53Elsevier
摘要:Les microparticules cellulaires jouent un rôle clé dans le contrôle de l’homéostasie vasculaire. S’il est clairement établi qu’elles représentent des vecteurs d’information biologique à multiples facettes (coagulation, inflammation, protéolyse), leur implicati...
作者:R. Pannell , A. Spandidos ...
来源:[J].Blood Cells, Molecules and Diseases(IF 2.259), 2001, Vol.27 (1), pp.249-259Elsevier
摘要:Abstract(#br)ABSTRACT(#br)Cancer arises because of genetic changes in somatic cells, eventually giving rise to overt malignancy. Principle among genetic changes found in tumor cells are chromosomal translocations which give rise to fusion genes or enforced oncogene expressio...
作者:R. PANNELL , W. KUNG , V. GUREWICH
来源:[J].Journal of Thrombosis and Haemostasis(IF 6.081), 2007, Vol.5 (5), pp.1047-1054Wiley
摘要:Summary. Background: Prourokinase (prouPA) is unstable in plasma at therapeutic concentrations. A mutant form, M5, made more stable by reducing its intrinsic activity was therefore developed. Activation to two‐chain M5 (tcM5) induced a higher catalytic activity than two‐chai...
作者:R. PANNELL , A. SIMMONS‐BYRD ...
来源:[J].Journal of Thrombosis and Haemostasis(IF 6.081), 2006, Vol.4 (7), pp.1559-1565Wiley
摘要:Summary. Background: A single site mutant (M5) of prourokinase (proUK) was developed to make proUK less vulnerable to spontaneous activation in plasma. This was a problem that seriously compromised proUK in clinical trials, as it precluded proUK‐mediated fibrinolysis at ther...

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