全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... E Smith , C W Archer , R G Richards
来源:[J].European Cells and Materials (ECM)(IF 4.558), 2006, Vol.11, pp.57DOAJ
摘要:This paper introduces the culture preparation of ovine, bovine and human cancellous bone cores to be used in an explants model Zetos. The three dimensional (3D) bone cores were prepared and evaluated for all three animals. Bone cells in vivo constantly interact with each other, m...
作者:... A Simpson , C M Davies , R G Richards
来源:[J].European Cells and Materials (ECM)(IF 4.558), 2006, Vol.12, pp.16DOAJ
摘要:Biocompatibility studies are carried out either in two dimensional monolayer culture or in animal studies. Bone organ cultures are therefore required in order to reduce the number of animal studies performed, while at the same time ensuring a more natural environment than th...
作者:R G Richards , S Milz ...
来源:[J].European Cells and Materials (ECM)(IF 4.558), 2007, Vol.13, pp.1DOAJ
摘要:Development of an optimal interface between bone and orthopaedic and dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo...
作者:R G Richards , Z Y Zhou
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.1-14European Cells and Materials (eCM)
摘要:Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the main source of extracellular pyrophosphate. Along with tissue-nonspecific alkaline phosphatase (TNAP), ENPP1 plays an important role in balancing bone mineralisation. Although well established in pre-osteoblasts, t...
作者:R G Richards , D W Grijpma ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.35, pp.151-164European Cells and Materials (eCM)
摘要:Antibiotic-loaded biomaterials (ALBs) have emerged as a potential useful adjunctive antimicrobial measure for the prevention of infection in open fracture care. A biodegradable thermo-responsive poly(N-isopropylacrylamide) grafted hyaluronic acid (HApN) hydrogel loaded with genta...
作者:R G Richards , S Nijs
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.184-199European Cells and Materials (eCM)
摘要:A fracture-related infection (FRI) is an important complication that can lead to an increase in morbidity, mortality and economic costs. Preclinical in vivo models are critical in the evaluation of novel prevention and treatment strategies, yet it is important that these studies ...
作者:... D Nehrbass , R G Richards , T F Moriarty
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.321-340European Cells and Materials (eCM)
摘要:Fracture-related infection (FRI) is a major complication in surgically fixed fractures. Instability of the fracture after fixation is considered a risk factor for infection; however, few experimental data are available confirming this belief. To study whether stable fractures led...
作者:... I Zderic , R G Richards , T F Moriarty
来源:[J].Eur Cell Mater(IF 4.558), 2015, Vol.30, pp.148-162European Cells and Materials (eCM)
摘要:The local mechanical environment at a fracture is known to influence biological factors such as callus formation, immune cell recruitment and susceptibility to infection. Infection models incorporating a fracture are therefore required to evaluate prevention and treatment of infe...
作者:... E M Schwarz , S Zeiter , R G Richards
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.83-98European Cells and Materials (eCM)
摘要:The treatment of chronic orthopaedic device-associated infection (ODRI) often requires multiple surgeries and prolonged antibiotic therapy. Despite this extensive treatment protocol, the procedure is associated with significant failure rates. Currently, no large animal model is a...
作者:... A Quail , R G Richards , Z J Balogh
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.99-107European Cells and Materials (eCM)
摘要:Morbidity associated with femur fractures in polytrauma patients is known to be high. The many unsolved clinical questions include the immunological effect of the fracture and its fixation, timing of fracture fixation, management of fracture non-union, effect of infection an...

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