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作者:Pierre H. Mangin , David Brasse
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2018, Vol.61, pp.21-27
摘要:Abstract(#br)Introduction(#br)Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represe...
作者:... Christian Gachet , Pierre H. Mangin , Li Zhu
来源:[J].Thrombosis Research(IF 3.133), 2016, Vol.141, pp.49-57
摘要:Abstract(#br)Objective(#br)Vascular plug formation by mechanical injury that exposes abundant extracellular matrix is an ideal model to mimic thrombus formation. The objective of this study was to standardize our previously established in vivo mouse model of thrombus formati...
作者:... Mathieu Schaff , Christian Gachet , Pierre H. Mangin
来源:[J].Cancers, 2017, Vol.9 (10)
摘要:Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. While the role of platele...
作者:... Christian Gachet , François Lanza , Pierre H. Mangin
来源:[J].Arteriosclerosis, Thrombosis, and Vascular Biology(IF 6.338), 2011, Vol.31 (1), pp.117-124
摘要:OBJECTIVE—: The identification of platelet-reactive proteins exclusively present in atherosclerotic plaques could provide interesting targets for effective and safe antithrombotic strategies. In this context, we explored platelet adhesion and activation to tenascin-C (TN-C),...
作者:... Christian Gachet , François Lanza , Pierre H. Mangin
来源:[J].Circulation(IF 15.202), 2013, Vol.128 (5), pp.541-552
摘要:BACKGROUND—: Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α...
作者:Pierre H. Mangin , Franç ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1101-1114
摘要:The combined action of collagen and thrombin induces the formation of COAT platelets, which are characterised by a coat of procoagulant and adhesive molecules on their surface. Although recent work has started to highlight their clinical relevance, the exact mechanisms regulating...
作者:... Christian Gachet , Pierre H. Mangin , Martine Jandrot-Perrus
来源:[J].Blood, 2015, Vol.126 (5), pp.683-691
摘要:Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as-yet-unidentified receptor is thought to mediate platelet interaction with fibrin....
作者:... ois Lanza , Christian Gachet , Pierre H. Mangin
来源:[J].Thromb Haemost(IF 6.094), 2015, Vol.114 (6), pp.1175-1188
摘要:The ability of cellular fibronectin, found in the vessel wall in a fibrillar conformation, to regulate platelet functions and trigger thrombus formation remains largely unknown. In this study, we evaluated how parietal cellular fibronectin can modulate platelet responses under fl...
作者:... Mathieu Schaff , Christian Gachet , Pierre H. Mangin
来源:[J].Cancers, 2017, Vol.9 (10)
摘要:Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. While the role of platele...
作者:... Benoit Ho Tin Noé , Martine Jandrot-Perrus , Pierre H. Mangin
来源:[B].Springer International Publishing2017
摘要:Abstract Platelet membrane glycoprotein VI has been identified relatively recently as compared to other major platelet glycoproteins such as the GPIb-V-IX complex and integrin α IIb β 3 . This is probably due to the poor clinical manifestations associated to a GPVI deficienc...

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