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作者:... Alexander S. Rose , Johanna K. S. Tiemann , Peter W. Hildebrand
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Single-particle analysis of electron cryo-microscopy (cryo-EM) is a key technology for elucidation of macromolecular structures. Recent technical advances in hardware and software developments significantly enhanced the resolution of cryo-EM density maps and broadened the applica...
作者:Peter W. Hildebrand , Dietmar Schmitz ...
来源:[J].EMBO Molecular Medicine(IF 7.795), 2012, Vol.4 (7), pp.647-659Wiley
摘要:Abstract(#br)Here, we describe a novel missense mutation in the amyloid precursor protein (APP) causing a lysine‐to‐asparagine substitution at position 687 (APP770; herein, referred to as K16N according to amyloid‐β (Aβ) numbering) resulting in an early onset dementia w...
作者:Peter W. Hildebrand , Alexander S. Rose , Johanna K.S. Tiemann
来源:[J].Trends in Biochemical Sciences(IF 13.076), 2019Elsevier
摘要:Molecular dynamics (MD) simulations monitor time-resolved motions of macromolecules. While visualization of MD trajectories allows an instant and intuitive understanding of dynamics and function, so far mainly static representations are provided in the published literature. Recen...
作者:Peter W. Hildebrand , Chang-Shung Tung ...
来源:[J].Cell(IF 31.957), 2014, Vol.158 (1), pp.121-131Elsevier
摘要:Summary(#br)The extent to which bacterial ribosomes and the significantly larger eukaryotic ribosomes share the same mechanisms of ribosomal elongation is unknown. Here, we present subnanometer resolution cryoelectron microscopy maps of the mammalian 80S ribosome in the post...

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