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作者:Peter Schraml , Holger Moch
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total tr...
作者:Peter Schraml , Fraser Symmans ...
来源:[J].Breast Cancer Research(IF 5.872), 2017, Vol.19 (1)
摘要:Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ ERBB2 ), estrogen receptor (ER/ ESR1 ), progesterone receptor (PgR/ PGR ), and marker of proliferation Ki67 ( MKI67 ) is indispensable for therapeutic decision making in early br...
作者:... Niko Beerenwinkel , Holger Moch , Peter Schraml
来源:[J].Neoplasia, 2019, Vol.21 (2), pp.247-256
摘要:Abstract(#br)Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in most clear cell renal cell carcinomas (ccRCC). Frequent gene alterations were also identified in SETD2 , BAP1 and PBRM1, all of which are situated on chromosome 3p and encode hi...
作者:... Holger Moch , Karsten Henco , Peter Schraml
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (8)
摘要:Despite the individually different molecular alterations in tumors, the malignancy associated biological traits are strikingly similar. Results of a previous study using renal cell carcinoma (RCC) as a model pointed towards cancer-related features, which could be visualized as th...
作者:Peter Schraml , Frank L Heppner
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (3)
摘要:The O(6)-methylguanine-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. First clinical reports on treating brain metastases with temozolomide describe varying effects. T...
作者:Peter Schraml , Holger Moch ...
来源:[J].Nature Medicine(IF 22.864), 2017, Vol.23 (9), pp.1046-1054
摘要:Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase complex, result in opposing degradation activity of BET proteins and response to BET inhibitors. This work, along with find...
作者:... Mark A Rubin , Holger Moch , Peter Schraml
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (1)
摘要:Abstract(#br) Background(#br)Chimeric read-through RNAs are transcripts originating from two directly adjacent genes (<10 kb) on the same DNA strand. Although they are found in next-generation whole transcriptome sequencing (RNA-Seq) data on a regular basis, investigating them fu...
作者:Peter Schraml , Georg Schwerdtfeger ...
来源:[J].The American Journal of Pathology(IF 4.522), 2003, Vol.163 (3), pp.985-992
摘要:Amplification of chromosomal regions leads to an increase of DNA copy numbers and expression of oncogenes in many human tumors. The identification of tumor-specific oncogene targets has potential diagnostic and therapeutic implications. To identify distinct spectra of oncoge...
作者:Peter Schraml , Alexander Hergovitz ...
来源:[J].The American Journal of Pathology(IF 4.522), 2003, Vol.163 (3), pp.1013-1020
摘要:Alterations of the von Hippel-Lindau tumor-suppressor gene ( VHL ) on 3p25-p26 are frequent in clear-cell renal-cell carcinoma (RCC). The VHL protein (pVHL) is implicated in cell-cycle control and gene regulation, and requires transcription-dependent nuclear-cytoplasmic trafficki...

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