全部文献期刊会议图书|学者科研项目
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作者:Peter Schirmacher , Thomas Kirchner ...
来源:[J].Virchows Archiv(IF 2.676), 2017, Vol.471 (4), pp.509-520
摘要:The European Commision (EC) recently approved osimertinib for the treatment of adult patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) harboring EGFR T790M mutations. Besides tissue-based testing, blood samples containing cell-free circulating tumor ...
作者:... Balázs Győrffy , Peter Schirmacher , Albrecht Stenzinger
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)
摘要:Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that ...
作者:Peter Schirmacher , Christoph Plass ...
来源:[J].Clinical Sarcoma Research, 2017, Vol.7 (1)
摘要:Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentation, histopathological features, and additional molecular characteristi...
作者:Peter Schirmacher , Andreas Jung
来源:[J].Journal of Thoracic Oncology(IF 4.473), 2020
摘要:Abstract(#br)Introduction(#br)Tumor mutational burden (TMB) is a quantitative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole-exome sequencing (wesTMB) and gene panel sequencing (psTMB)...
作者:... Norbert Gretz , Peter Schirmacher , Kai Breuhahn
来源:[J].Cancer Letters(IF 4.258), 2020, Vol.473, pp.164-175
摘要:Abstract(#br)The Hippo pathway effectors yes-associated protein (YAP) and WW domain containing transcription regulator 1 (TAZ/WWTR1) support tumor initiation and progression in various cancer entities including hepatocellular carcinoma (HCC). However, to which extent YAP and...
作者:... Volker Endris , Peter Schirmacher , Albrecht Stenzinger
来源:[J].Lung Cancer(IF 3.392), 2020, Vol.142, pp.114-119
摘要:Abstract(#br)Objectives(#br)Retrospective data including subgroup analyses in clinical studies have sparked strong interest in developing tumor mutational burden (TMB) as a predictive biomarker for immune checkpoint blockade. While individual factors influencing panel sequen...
作者:Peter Schirmacher , Wilfried Roth
来源:[J].The American Journal of Pathology(IF 4.522), 2019, Vol.189 (8), pp.1547-1558
摘要:Lipid droplets, a morphologic feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT ( p erilipin, a dipophilin, and t ail-interacting protein of 47 kD) family. So far, the use of perilipins as markers for differential diagnosis of soft t...

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