全部文献期刊会议图书|学者科研项目
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作者:Peter M. Elias , Miroslav Blumenberg
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2017, Vol.137 (9), pp.1868-1877
摘要:AP1 transcription factors are important controllers of gene expression in the epidermis, and altered AP1 factor function can perturb keratinocyte proliferation and differentiation. However, our understanding of how AP1 signaling changes may underlie or exacerbate skin disease is ...
作者:Peter M. Elias , Guenter Haemmerle ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2017, Vol.137 (2), pp.394-402
摘要:Mutations in PNPLA1 have been identified as causative for autosomal recessive congenital ichthyosis in humans and dogs. So far, the underlying molecular mechanisms are unknown. In this study, we generated and characterized PNPLA1-deficient mice and found that PNPLA1 is crucial fo...
作者:Peter M. Elias , Achim Lass ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2017, Vol.137 (2), pp.403-413
摘要:Adipose triglyceride lipase (ATGL) and its coactivator comparative gene identification-58 (CGI-58) are limiting in cellular triglyceride catabolism. Although ATGL deficiency is compatible with normal skin development, mice globally lacking CGI-58 die postnatally and exhibit ...
作者:... Kenneth R. Feingold , Peter M. Elias , Mao-Qiang Man
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2017, Vol.137 (6), pp.1277-1285
摘要:Even though elderly populations lack visible or other clinical signs of inflammation, their serum cytokine and C-reactive protein levels typically are elevated. However, the origin of age-associated systemic inflammation is unknown. Our previous studies showed that abnormali...
作者:Peter M. Elias , Robert Gruber ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2017, Vol.137 (3), pp.706-715
摘要:Loss-of-function mutations in the FLG gene cause ichthyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD). Although both conditions are characterized by epidermal barrier impairment, AD also exhibits signs of inflammation. This ...
作者:... Joan S. Wakefield , Denis Khnykin , Peter M. Elias
来源:[J].The American Journal of Pathology(IF 4.522), 2018, Vol.188 (6), pp.1419-1429
摘要:Mutations in several lipid synthetic enzymes that block fatty acid and ceramide production produce autosomal recessive congenital ichthyoses (ARCIs) and associated abnormalities in permeability barrier homeostasis. However, the basis for the phenotype in patients with NIPAL4...
作者:... Robert Gruber , Matthias Schmuth , Peter M. Elias
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2019, Vol.139 (4), pp.760-768
摘要:The corneocyte lipid envelope (CLE), a monolayer of ω-hydroxyceramides whose function(s) remain(s) uncertain, is absent in patients with autosomal recessive congenital ichthyoses with mutations in enzymes that regulate epidermal lipid synthesis. Secreted lipids fail to trans...

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