全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Penjweini Rozhin , Andreoni Alessio ...
来源:[J].Journal of biomedical optics, 2018, Vol.23 (10), pp.1-14PubMed
摘要:Oxygen (O2) is one of the most important biometabolites. In abundance, it serves as the limiting terminus of aerobic respiratory chains in the mitochondria of higher organisms; in deficit, it is a potent determinant of development and regulation of other physiological and therape...
作者:Penjweini Rozhin , Loew Hans G ...
来源:[J].Photodiagnosis and photodynamic therapy, 2013, Vol.10 (4), pp.591-9PubMed
摘要:Photodynamic therapy (PDT) is based on the preferential accumulation of photosensitizer in cancer cells with subsequent cytotoxicity mediated by singlet oxygen production after light excitation. As photosensitizers accumulate also in the surrounding non-cancer cells, the risk of ...
作者:Penjweini Rozhin , Smisdom Nick ...
来源:[J].Biochimica et biophysica acta, 2014, Vol.1843 (5), pp.855-65PubMed
摘要:PVP-Hypericin (PVP: polyvinylpyrrolidone) is a potent anti-cancer photosensitizer for photodynamic diagnosis (PDD) and therapy (PDT). However, cellular targets and mechanisms involved in the cancer-selectivity of the photosensitizer are not yet fully understood. This paper gives ...
作者:Penjweini Rozhin , Deville Sarah ...
来源:[J].Journal of controlled release : official journal of the Controlled Release Society, 2015, Vol.218, pp.82-93PubMed
摘要:The study of cell-nanoparticle interactions is an important aspect for understanding drug delivery using nanocarriers. In this regard, advances in fluorescence based microscopy are useful for the investigation of temporal and spatial behavior of nanoparticles (NPs) within the int...
作者:Penjweini Rozhin , Finlay Jarod C ...
来源:[J].Photochemistry and photobiology, 2017, Vol.93 (4), pp.1115-1122PubMed
摘要:This preclinical study examines light fluence, photodynamic therapy (PDT) dose and "apparent reacted singlet oxygen," [1 O2 ]rx , to predict local control rate (LCR) for Photofrin-mediated PDT of radiation-induced fibrosarcoma (RIF) tumors. M...
作者:... Kim Michele M , Penjweini Rozhin , Zhu Timothy C
来源:[J].Journal of biomedical optics, 2016, Vol.21 (8), pp.88002PubMed
摘要:Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates ( ? ). A macroscopic model was adopted ...
作者:Kim Michele M , Penjweini Rozhin , Zhu Timothy C
来源:[J].Journal of biomedical optics, 2017, Vol.22 (2), pp.28002PubMed
摘要:Existing dosimetric quantities do not fully account for the dynamic interactions between the key components of photodynamic therapy (PDT) or the varying PDT oxygen consumption rates for different fluence rates. Using a macroscopic model, reacted singlet oxygen ( [ O 2 1 ] rx ) wa...

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