全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Cristina C. Barrias , Paulo J. Bártolo , Pedro L. Granja
来源:[J].Acta Biomaterialia(IF 5.093), 2018, Vol.66, pp.282-293Elsevier
摘要:Abstract(#br)Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrossli...
作者:... Carla Oliveira , Pedro L. Granja , Bruno Sarmento
来源:[J].Acta Biomaterialia(IF 5.093), 2018Elsevier
摘要:Abstract(#br)Targeting of CD44 isoforms containing exon v6 (CD44v6) represents a viable strategy for the therapy and/or early diagnosis of metastatic cancers of the epithelium (e.g. gastric and colorectal cancer). We developed and characterized poly(lactic-co-glycolic acid) ...
作者:... Carla Oliveira , Cristina C. Barrias , Pedro L. Granja
来源:[J].Acta Biomaterialia(IF 5.093), 2018Elsevier
摘要:Abstract(#br)The field of stomach-directed therapeutics and diagnosis is still hampered by the lack of reliable in vitro models that closely mimic the gastric mucosa where gastric cancer cells are generally confined. Here we propose a rapid, complex, and innovative 3D in vit...
作者:... Daniela M. Sousa , Pedro L. Granja , José M.F. Ferreira
来源:[J].Acta Biomaterialia(IF 5.093), 2015, Vol.15, pp.210-226Elsevier
摘要:Abstract(#br)The present work is an amalgamation of computation and experimental approach to gain an insight into composition–structure–bioactivity relationships of alkali-free bioactive glasses in the CaO–MgO–SiO 2 –P 2 O 5 system. The glasses have been designed i...
作者:Sílvia J. Bidarra , Cristina C. Barrias , Pedro L. Granja
来源:[J].Acta Biomaterialia(IF 5.093), 2014, Vol.10 (4), pp.1646-1662Elsevier
摘要:Abstract(#br)Alginate hydrogels are extremely versatile and adaptable biomaterials, with great potential for use in biomedical applications. Their extracellular matrix-like features have been key factors for their choice as vehicles for cell delivery strategies aimed at tissue re...
作者:... Cristina C. Barrias , Pedro L. Granja , Bruno Sarmento
来源:[J].Biomaterials(IF 7.604), 2015, Vol.56, pp.36-45Elsevier
摘要:Abstract(#br)Absorption evaluation plays an increasingly important role at the early stage of drug discovery due to its potential to scan the ADME (absorption, distribution, metabolism and excretion) properties of new drug candidates. Therefore, a new three-dimensional (3D) in vi...
作者:Pedro L. Granja , Hélder A. Santos
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (33), pp.9199-9207Elsevier
摘要:Abstract(#br)Glucagon like peptide-1 (GLP-1) is an incretin hormone that is in the pipeline for type 2 diabetes mellitus (T2DM) therapy. However, oral administration of GLP-1 is hindered by the harsh conditions of the gastrointestinal tract and poor bioavailability. In this study...
作者:... Ovijit Chaudhuri , Pedro L. Granja , David J. Mooney
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (32), pp.8927-8936Elsevier
摘要:Abstract(#br)Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understoo...
作者:... Fátima Carneiro , Pedro L. Granja , David J. Mooney
来源:[J].Biomaterials(IF 7.604), 2016, Vol.98, pp.152-162Elsevier
摘要:Abstract(#br)Two-dimensional (2D) cultures often fail to mimic key architectural and physical features of the tumor microenvironment. Advances in biomaterial engineering allow the design of three-dimensional (3D) cultures within hydrogels that mimic important tumor-like feat...
作者:... Gabriela Rodrigues , Pedro L. Granja , Cristina C. Barrias
来源:[J].Acta Biomaterialia(IF 5.093), 2014, Vol.10 (7), pp.3197-3208Elsevier
摘要:Abstract(#br)Mesenchymal stem cells (MSCs) can be made to rearrange into microtissues in response to specific matrix cues, a process that depends on a balance between cell–matrix and cell–cell interactions. The effect of such cues, and especially their interplay, is still no...

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